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Nicola Pozzi: A Brand-New Mechanism to Reduce Thrombosis Without Increasing Bleeding Risk
Photo: biochem.slu.edu
Mar 13, 2026, 15:59

Nicola Pozzi: A Brand-New Mechanism to Reduce Thrombosis Without Increasing Bleeding Risk

Nicola Pozzi, Associate Professor of Thrombosis and Hemostasis and Autoimmunity at Saint Louis University School of Medicine, shared a post on LinkedIn about a recent article he and his collegues co-authored, adding:

“From structure, to function, to proof-of-concept therapeutic.

A brand-new mechanism to reduce thrombus formation without increasing bleeding risk inspired by our research on Antiphospholipid Syndrome (APS).

Extremely proud of this work, how it has evolved over the years and the incredible people involved (Marisa Brake, Suresh Kumar, Catherine Lapointe, Glenn Merrill-Skoloff, Sol Schulman, Matthew Flick, and Robert Flaumenhaft at Harvard Medical School, Saint Louis University School of Medicine and Blood Research Center at UNC)

We believe this approach has great potential, and we’re excited to moving it forward.

Also, here’s an interesting research question.

Are all autoantibodies bad?

Early to say but maybe not all of them are…”

Title: In vivo targeting of open prothrombin with the monoclonal antibody POmAb results in anticoagulation without excessive bleeding

Authors: Marisa A Brake, Suresh Kumar, Catherine Lapointe, Glenn Merrill-Skoloff, Sol Schulman, Matthew J Flick, Robert Flaumenhaft, Nicola Pozzi

Read the Full Article on JTH

Nicola Pozzi: A Brand-New Mechanism to Reduce Thrombosis Without Increasing Bleeding Risk

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Antiphospholipid Syndrome APS bleeding disorders Catherine Lapointe Glenn Merrill-Skoloff Headlines Health Hematology Hemostasis News Hemostasis Today Journal of Thrombosis and Haemostasis JTH Marisa A. Brake Marisa Brake Matthew Flick Matthew J. Flick Medicine Nicola Pozzi Robert Flaumenhaft Sol Schulman Suresh Kumar
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