Saleh Shamse Basha/LinkedIn
Jun 26, 2026, 07:10
Saleh Shamse Basha: Why APTT Alone Can Be Misleading During UFH Monitoring
Saleh Shamse Basha, Senior Hematology Technologist (Reference Lab, HQ) at PureLab, shared a post on LinkedIn:
“A patient post surgical inflammation on unfractionated heparin (UFH).
APTT: 66 sec.
In thise case can you relay on APTT alone to monitor the UFH??
The answer is : No.
But, Why?
During the acute-phase response, Factor VIII is often elevated.
Increased FVIII shortens the APTT, meaning that an APTT of 66 seconds may underestimate the true anticoagulant effect of UFH.
That’s the trap.
That’s why we should use Anti-Xa assay while monitoring patient on UFH.”
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