Shadi Tabibian: Global Trends in Prenatal Diagnosis of Hemophilia A and B Over Two Decades
Shadi Tabibian, Director of the Iranian Comprehensive Hemophilia Care Center (ICHC) and Deputy of research at Blood Diseases Research Centers, Iran University of Medical Sciences, shared a post on LinkedIn about a recent article she and her colleagues co-authored, adding:
“Proud to share our new publication:
‘Two decades of prenatal diagnosis in hemophilia A and B: a systematic review of global trends and current practices.’
In this PRISMA-guided systematic review, we mapped global trends in prenatal diagnosis (PND) for hemophilia A and B over the last 20 years (2005–September 2025). We included 24 studies covering 969 pregnancies.
Key highlights
- Predominant sampling approaches: amniocentesis (45.8%) and CVS (41.6%)
- A clear methodological shift from linkage analysis toward more definitive molecular strategies, including PCR and direct sequencing (each reported in 45.8% of studies)
- cfDNA/NIPT is emerging (reported in 20.8% of studies), but broader validation and implementation pathways remain needed
- Persistent gaps: substantial heterogeneity in access/reporting and limited pregnancy outcome data in many reports
Overall, the field has advanced substantially – yet there remains a critical need for standardized reporting, equitable access to genetic services, and stronger evidence to support non-invasive pathways.”
Title: Two decades of prenatal diagnosis in hemophilia A and B: a systematic review of global trends and current practices
Authors: Seyed Mehrab Safdari, Mehdi Bakhtiyaridovvombaigi, Fatemeh Damerchiloo, Akram Sadat Jaafarian, Fateme Amiri Samani, Majid Safa, Shadi Tabibian
Read the Full Article on Thrombosis Journal
Stay updated with Hemostasis Today.
-
Apr 14, 2026, 17:32Denise M.: Surviving Sepsis 2026 – The Upstream Revolution
-
Apr 14, 2026, 17:23Meghanath Yenni։ What’s New in Acute Ischemic Stroke in 2026
-
Apr 14, 2026, 17:11Phil Spinella: What Dose of TXA for Children With Severe Traumatic Bleeding Should You Use?
-
Apr 14, 2026, 17:08Abdulrahman Katib: How Endovascular Stenting Is Transforming the Treatment of Severe PTS
-
Apr 14, 2026, 17:00Anna A. Avagyan: Glad to Be Part of EHA Pediatric Hematology-Oncology Course
-
Apr 14, 2026, 16:58Ney Carter Borges: NLRP3 Inhibition in Atherosclerosis – Early Clinical Signal Beyond Lipids
-
Apr 14, 2026, 16:56Saskia Middeldorp: Key Takeaways from the 2026 ACC/AHA Guideline on Acute PE
-
Apr 14, 2026, 16:54Chokri Ben Lamine: Extracorporeal Photopheresis for aGVHD cGVHD Post-SCT – 50 Pearls
-
Apr 14, 2026, 16:49Ahmed Magdi Omar: Key Takeaways From the Latest 2026 Guidelines on Antiplatelet Therapy in AIS