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Shiny K. Kajal: Not All Transfusion Reactions Are Immunohematologic Incompatibilities
Shiny K. Kajal/LinkedIn
Feb 22, 2026, 09:22

Shiny K. Kajal: Not All Transfusion Reactions Are Immunohematologic Incompatibilities

Shiny K. Kajal, Senior Resident at Adesh University, shared a post on LinkedIn:

“Washed PRBCs – Precision Beyond Compatibility

Not all transfusion reactions are immunohematologic incompatibilities.

Sometimes, the culprit is residual plasma.

Washed PRBCs are red cell units processed to remove:

  • Plasma proteins
  • IgA
  • Cytokines
  • Bioactive mediators

Indicated in:

  • Severe IgA deficiency with anti-IgA
  • Recurrent severe allergic transfusion reactions
  • Selected neonatal exchange transfusions

Limitations:

  • 24-hour shelf life (post-processing)
  • RBC loss during washing
  • Increased cost and labor

Clinical Insight: Washed red cells are not about matching better —they are about transfusing less of what should not be there.”

Shiny K. Kajal: Not All Transfusion Reactions Are Immunohematologic Incompatibilities

Find more posts featuring Shiny K. Kajal on Hemostasis Today.

Health Hematology Hemostasis Hemostasis News Hemostasis Today Medicine RBC residual plasma Shiny K Kajal Transfusion Medicine Washed PRBC
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