William Aird/X
Sep 25, 2025, 05:56
William Aird: Why Does The PLASMIC Score For TTP Include A “Low” MCV?
William Aird, Professor of Medicine at Harvard Medical School, posted on X:
” 1/2
LOW MEAN CELL VOLUME AS MARKER OF TTP
Why does the PLASMIC score for TTP include a “low” MCV?
Because schistocytes are, by definition, smaller than mature RBCs → ↓MCV.
2/2
Why is the cutoff in the PLASMIC score <90 fL (not <80, which is lower limit of normal)?
Because the drop is modest (schistocytes are few vs intact RBCs) and because it’s partly offset by reticulocytosis (↑MCV).
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