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David Teboul Shares NIH Research: Translating Cryo-EM Structures into Therapeutic Insights for Heart Disease
David Teboul/LinkedIn
Nov 7, 2025, 03:27

David Teboul Shares NIH Research: Translating Cryo-EM Structures into Therapeutic Insights for Heart Disease

David Teboul, Life Sciences Electron Microscopy Account Manager at Thermo Fisher Scientific, posted on LinkedIn:

“New Research: Clinical Samples Used in Cryo-EM Study of LDL Metabolism

Researchers at National Institute of Allergy and Infectious Diseases (NIAID) and National Heart, Lung, and Blood Institute have used clinical samples in cryo-electron microscopy (cryo-EM) to explore mechanisms of lipid metabolism. One of the lead authors, Dr. Altaira Dearborn, a staff scientist in Dr. Joseph Marcotrigiano’s lab at NIAID (NIH), is working to use “real-world” samples—applying cryo-EM single particle analysis to proteins directly isolated from human patients to uncover disease mechanisms at near-atomic resolution.

This study sheds new light on LDL (low-density lipoprotein) recognition and uptake. The findings not only deepen our understanding of cholesterol metabolism but also offer promising directions for therapeutic development in atherosclerosis and related cardiovascular diseases.

A great example of how structural biology and translational research can converge to impact human health.”

Title: Structure of apolipoprotein B100 bound to the low-density lipoprotein receptor

Authors: Mart Reimund, Altaira D. Dearborn, Giorgio Graziano, Haotian Lei, Anthony M. Ciancone, Ashish Kumar, Ronald Holewinski, Edward B. Neufeld, Francis J. O’Reilly, Alan T. Remaley, Joseph Marcotrigiano

David Teboul Shares NIH Research: Translating Cryo-EM Structures into Therapeutic Insights for Heart Disease

Read full article here.

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Alan T. Remaley Altaira D. Dearborn Anthony M. Ciancone Ashish Kumar Edward B. Neufeld Francis J. O’Reilly Giorgio Graziano Haotian Lei Health Hematology Hemostasis Hemostasis Today Joseph Marcotrigiano LDL (low-density lipoprotein) Mart Reimund Medicine National Heart Lung and Blood Institute National Institute of Allergy and Infectious Diseases (NIAID) NIH Ronald Holewinski
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