Grégoire Le Gal: Using an Age-Adjusted D-Dimer Cutoff Safely Excluded DVT
Marc Carrier, Professor at Ottawa Hospital Research Institute, shared a post on LinkedIn:
“New publication in JAMA
Age-adjusted D-dimer can safely rule out suspected DVT
A large multinational prospective management study (n = 3,205 outpatients) provides strong evidence that age-adjusted D-dimer thresholds are not only valid for PE, but also for suspected lower-limb DVT!
Key findings
Using an age-adjusted D-dimer cutoff (age × 10 µg/L for patients ≥50 years) safely excluded DVT
No venous thromboembolic events at 3 months among patients with D-dimer levels between 500 µg/L and their age-adjusted cutoff
+7.4% absolute increase in the proportion of patients in whom DVT could be ruled out without imaging
Reduces unnecessary compression ultrasonography, same safety.
Congratulations to Drs. Grégoire LE GAL, Marc Righini, Helia Robert-Ebadi and the whole team for this important contribution.”
Title: Age-Adjusted D-Dimer Cutoff Levels to Rule Out Deep Vein Thrombosis
Authors: Grégoire Le Gal, Helia Robert-Ebadi, Venkatesh Thiruganasambandamoorthy, Fares Moustafa, Andrea Penaloza, Judith Catella, Marie Chevallier Grenot, Shaun Visser, Lucia Mazzolai, Alain Plumacker, Stefano Barco, Eddy Lang, Vicky Tagalakis, Claire Deroche, Meghan Garnett, Jennifer Hulme, Pierre-Marie Roy, Alexandre Ghuysen, Francis Couturaud, Rolf Engelberger, Dominique El Kouri, Drahomir Aujesky, Marc Righini, ADJUST-DVT Investigators
Read full article here.
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