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Inflammation: How VWF Influences Neutrophil Function
Sep 19, 2025, 00:52

Inflammation: How VWF Influences Neutrophil Function

Hamideh Yadegari, Senior Scientist, University Clinic Bonn, shared a post on LinkedIn:

“I’m happy to share our latest study, just published in Haematologica.
Even though the early view of this paper has been available since the beginning of the year, I’m pleased that it is now accessible in its final full-text journal format.

There is a growing body of evidence showing that von Willebrand factor (VWF) plays roles beyond hemostasis, particularly in inflammation. Its function appears to be quite complex—ranging from intracellular effects, such as the formation of Weibel Palade bodies, to interactions with macrophages and its elevated levels observed in various inflammatory disorders.

In this study, we show for the first time that even circulating VWF can interact directly with neutrophils, influence their behavior, and become internalized. This suggests a novel mechanism by which VWF may modulate neutrophil function and contribute to its own clearance from the bloodstream.”

Title: Interplay between circulating von Willebrand factor and neutrophils: implications for inflammation, neutrophil function, and von Willebrand factor clearance

Authors: Alua Kuanyshbek, Hamideh Yadegari, Jens Müller, Nasim Shahidi Hamedani, Samhitha Urs Ramaraje, Johannes Oldenburg

Inflammation: How VWF Influences Neutrophil Function

Read the article here.

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(inflammation Alua Kuanyshbek Blood Research Haematologica Hamideh Yadegari Health Hematology Hemostasis Hemostasis Today Immuno Hematology Immunology Jens Müller Johannes Oldenburg Medicine Nasim Shahidi Hamedani Neutrophil Function Samhitha Urs Ramaraje Von Willebrand Factor
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