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Matthew D Neal: Most of the World is a “Platelet Desert” – Which Innovations in Platelet Transfusion Will Be an Oasis, and Which are a Mirage?
Matthew D Neal/LinkedIn
Dec 19, 2025, 11:56

Matthew D Neal: Most of the World is a “Platelet Desert” – Which Innovations in Platelet Transfusion Will Be an Oasis, and Which are a Mirage?

Matthew D Neal, Associate Professor of Surgery, Critical Care Medicine, and Clinical and Translational Science at University of Pittsburgh School of Medicine, shared on LinkedIn:

“Most of the world is a ‘platelet desert.’ Access to lifesaving platelet transfusions is lacking not only in low- and middle-income countries but also in major cities in the United States due to donor shortages and storage limitations. Rural areas have little to no available platelets, and platelets are absent from prehospital care where timely transfusion can save lives.

It was a pleasure to write this editorial for JAMA with Phil Spinella and Lucy Zumwinkle Kornblith. Here, we review the CLIP-II results and we tackle a challenging question –> which innovations in platelet transfusion will be an oasis, and which are a mirage?

Title: Cryopreserved vs Liquid-Stored Platelets for the Treatment of Surgical Bleeding: The CLIP-II Randomized Noninferiority Clinical Trial

Authors: Michael C. Reade, Denese C. Marks, Belinda D. Howe, Michael J. Bailey, Paul G. Bannon, Glenn M. Eastwood, Craig J. French, David J. Gattas, Alisa M. Higgins, Anthony D. Holley, Raymond T. Hu, David O. Irving, Lacey Johnson, Shay P. McGuinness, Zoe K. McQuilten, Alistair G. Royse, Julian A. Smith, Laurence Weinberg, Erica M. Wood, the Cryopreserved vs Liquid Platelets II (CLIP-II) Investigators, the Australian and New Zealand Intensive Care Society Clinical Trials Group, the Australian and New Zealand College of Anaesthetists Clinical Trials Network, the Australasian Society of Cardiac and Thoracic Surgeons

Matthew D Neal: Most of the World is a "Platelet Desert" - Which Innovations in Platelet Transfusion Will Be an Oasis, and Which are a Mirage?

Our editorial can be found here.

Title: An Oasis in the Platelet Desert?

Authors: Matthew D Neal, Philip C. Spinella, Lucy Z. Kornblith

Matthew D Neal: Most of the World is a "Platelet Desert" - Which Innovations in Platelet Transfusion Will Be an Oasis, and Which are a Mirage?

Comments and questions are welcome! This is THE fastest and most innovative area of trauma and transfusion medicine research.”

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Alisa M. Higgins Alistair G. Royse Anthony D. Holley Belinda D. Howe Craig J. French David J. Gattas David O. Irving Denese C. Marks Erica M Wood Glenn M. Eastwood Health Hemostasis Hemostasis Today JAMA Julian A. Smith Lacey Johnson Laurence Weinberg Lucy Z. Kornblith Lucy Zumwinkle Kornblith Matthew D. Neal Medicine Michael C. Reade Michael J. Bailey Paul G. Bannon Phil Spinella Philip C. Spinella platelet desert Raymond T. Hu Shay P. McGuinness the Australasian Society of Cardiac the Australian and New Zealand College of Anaesthetists Clinical Trials Network the Australian and New Zealand Intensive Care Society Clinical Trials Group the Cryopreserved vs Liquid Platelets II (CLIP-II) Investigators Thoracic Surgeons thrombosis Zoe K. McQuilten
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