NewsFeed Voices Science Insight Innovation
November, 2025
November 2025
M T W T F S S
 12
3456789
10111213141516
17181920212223
24252627282930
Samuel Nweke on Significance of MPV in a CBC in Diagnosis
Samuel Nweke/LinkedIn
Oct 14, 2025, 06:10

Samuel Nweke on Significance of MPV in a CBC in Diagnosis

Samuel Nweke, Deputy Lab Manager and Chairman of Quality Management Team at Malens Diagnostics, shared on LinkedIn:

”Significance of Mean Platelet Volume (MPV) in a Complete Blood Count (CBC) in Diagnosis

MPV:
Mean Platelet Volume (MPV) measures the average size of platelets in the blood.

It is automatically calculated by modern hematology analyzers.
Unit: femtoliters (fL)
Typical range: 7.5 – 11.5 fL

Platelet size reflects how active the bone marrow is in producing them.
Large platelets = younger, more reactive
Small platelets = older, less reactive

Interpretation of MPV Values:
Platelets circulate for about 8–10 days.

High MPV:
When platelet destruction increases (e.g., immune causes, inflammation, ITP), the bone marrow compensates by releasing larger, younger platelets — leading to a high MPV.

Low MPV:
When marrow production is suppressed or reduced (e.g., aplastic anemia, chemotherapy), the circulating platelets are smaller and fewer, resulting in a low MPV.

MPV and Platelet Count Relationship:
Low Platelet count + high MPV = Increased platelet destruction, marrow compensating (e.g., ITP)
Low Platelet count + low MPV = Decreased platelet production (e.g., marrow failure like aplastic anemia, leukemia, chemotherapy)
Low Platelet count + Normal MPV = Dilutional thrombocytopenia (e.g., massive transfusion) or splenic pooling
High Platelet count + high MPV = Myeloproliferative or inflammatory state

Normal platelet count + high MPV = Early platelet activation, inflammation, or cardiovascular risk marker

Calculation:
MPV = (PCT × 10⁴) ÷ PLT count

Where:
PCT: Plateletcrit, expressed as %
PLT: Platelet count in ×10⁹/L

Other Platelet Parameters:
P-LCR (Platelet Large Cell Ratio):
Percentage of large (young, newly released) platelets among total platelets.

P-LCC (Platelet Large Cell Count):

Absolute count of large platelets (volume >12 fL), expressed in ×10⁹/L.

PDW-SD (Platelet Distribution Width – Standard Deviation):
Reflects variability in platelet size, used to assess morphology and production.

PDW-CV (Platelet Distribution Width – Coefficient of Variation):
Quantifies degree of platelet anisocytosis (variation in size).

PCT (Plateletcrit):
Volume percentage (%) of platelets in whole blood. Similar to hematocrit (HCT) for red cells.
Understanding platelets will enable you to give a proper report on them.”

Stay updated with Hemostasis Today.

aplastic anemia CBC chemotherapy Health Hematology Hemostasis Hemostasis Today ITP Leukemia massive transfusion Medicine MPV Myeloproliferative state platelets Samuel Nweke thrombosis
NewsFeed