Surbhi Singh/LinkedIn
Oct 28, 2025, 06:54
Surbhi Singh: Hypersegmented Neutrophils – The Overachievers of the Myeloid World
Surbhi Singh, Consultant Haematopathology at Agilus Diagnostics and Fortis Hospital Gurugram, shared a post on LinkedIn:
“Hypersegmented Neutrophils
Meet the overachievers of the myeloid world!
Neutrophils with ≥5 lobes, flagging a nuclear maturation defect — most classically in megaloblastic anemia (B12 or folate deficiency) when the nucleus keeps dividing but the cytoplasm doesn’t keep pace.
Clue: If more than 5% of neutrophils have 5 lobes or any one neutrophil has ≥6 — time to think B12/folate deficiency.
Other Causes of Hypersegmented Neutrophils
- Myelodysplastic syndromes (MDS)
- Chemotherapy / cytotoxic drugs (e.g., methotrexate, hydroxyurea)
- DNA synthesis inhibitors (e.g., azathioprine, 5-FU)
- Chronic infections / inflammation
- Congenital neutrophil disorders (rare)
- Uremia (occasionally)
- Alcoholism / liver disease (nutritional + marrow toxicity factors).”
Stay updated with Hemostasis Today.
-
Dec 15, 2025, 15:58Khaled Musallam Applauds Hatoon Ezzat’s Leadership and Healthcare Advances in Saudi Arabia
-
Dec 15, 2025, 12:46Deborah Ebert Long on Hemophilia Care: Progress, Possibility, and the Power of Listening
-
Dec 15, 2025, 12:34Nathan Connell on Conversion from Eptacog Alfa to Beta
-
Dec 15, 2025, 12:17Danny Hsu on Interdisciplinary Toolkit for Gynecologic Bleeding on Anticoagulation
-
Dec 15, 2025, 12:08Ted Roh: A Historic Milestone for Indonesia’s Health Innovation
-
Dec 15, 2025, 11:28Wolfgang Miesbach Shares Insights from Davide Matino’s Presentation on Marstacimab at ASH25
-
Dec 15, 2025, 11:12Tushar Pandey Awarded for His Enourmous Contribution to Hematology
-
Dec 15, 2025, 11:07DISTRO: Vidya Rajbhoj on AI and Digital Technology to Improve Stroke Rehabilitation
-
Dec 15, 2025, 11:00Ischemic Stroke, AF and Atherosclerotis: Amira Khater on Sufficiency of Anticoagulant Monotherapy