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Tomaz Crochemore on Clot-Phenotyping’s Role in Prevention of Irreversible Organ Damage from Fibrinolysis Shutdown

Tomaz Crochemore/LinkedIn

Dec 1, 2025, 09:44

Tomaz Crochemore on Clot-Phenotyping’s Role in Prevention of Irreversible Organ Damage from Fibrinolysis Shutdown

Tomaz Crochemore, Fellow at the University of Zurich, shared on LinkedIn:

”Fibrinolysis shutdown is one of the most dangerous, and still under-recognized , phenotypes of thrombotic coagulopathy in critical care.

Seen in sepsis with organ dysfunction and in a significant subset of severely injured trauma patients, this hypofibrinolytic state locks the coagulation system in a pro-thrombotic overdrive, promoting microvascular clotting, tissue hypoperfusion, and progressive organ failure.

In trauma, patients who develop persistent fibrinolysis shutdown show a dramatically increased risk of death , with some cohorts reporting up to a five-fold rise in mortality compared with those who maintain physiologic fibrinolytic activity.

These data highlight a simple truth:
“we cannot manage what we do not measure”.

Early recognition through viscoelastic clot-phenotyping is essential to identify patients trapped in this thrombotic, hypofibrinolytic phenotype and to guide precision hemostatic interventions before irreversible organ damage occurs.”

Tomaz Crochemore on Clot-Phenotyping's Role in Prevention of Irreversible Organ Damage from Fibrinolysis Shutdown