Abdul Mannan: IVIG in ITP – When a Temporary Response Is a Success
Abdul Mannan, Consultant Haematologist, Director Haemophilia Centre, Haematology Lab Lead at Betsi Cadwaladr University Health Board, shared a post LinkedIn about a recent article by James B. Bussel and Jory M. Hirshman, published in Haematologica, adding:
“The platelet count rises after IVIG, then falls again two weeks later.
Has treatment failed?
Not necessarily.
In ITP, IVIG is often given to obtain a rapid, temporary platelet rise. The immediate aim may be to control bleeding, prepare for a procedure, or buy time for another treatment to work.
If that goal was achieved, IVIG may have succeeded, even though the response did not last.
A falling count still needs reassessment, particularly if bleeding returns or a procedure remains pending. Repeated rescue treatment should also prompt a discussion about sustained disease control.
The distinction matters when counselling patients: a platelet response, ongoing control, and treatment-free remission are different outcomes.
A transient response can be a successful rescue.”
Title: Where would immune thrombocytopenia be without intravenous gammaglobulin?
Authors: James B. Bussel, Jory M. Hirshman
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