Abhilasha Singh: A Novel Mechanism of Cardiac Aging and Disruption of The Neurovascular Network
Abhilasha Singh, Review Editor at Frontiers in Stroke, Reviewer at Springer Nature Phytomedicine, Frontiers in Neurology and AHA, shared on LinkedIn, about a recent article by Julian U. G. Wagner et al, published in Science:
”Aging Impairs the Heart’s Neurovascular Interface
A recent Science (2026) study highlights a novel mechanism of cardiac aging: disruption of the neurovascular network within the heart.
Key Findings
- Aging reduces cardiac nerve density, particularly in the ventricles
- Altered signaling pathways (low miR-145, high semaphorin-3A) impair neurovascular integrity
- This contributes to microvascular dysfunction and electrical instability
- Clearance of senescent cells restored nerve density and improved cardiac electrical function in aged models
Why This Matters
- Moves beyond traditional risk factors (lipids, BP)
- Identifies neurovascular aging as a structural driver of arrhythmia risk
- Links cellular senescence directly to cardiac electrical dysfunction
- Opens potential therapeutic avenues targeting senescence and nerve-vascular signaling
Big Takeaway
Cardiac aging is not only vascular or metabolic — it is also neurobiological.
Understanding the aging heart may require integrating vascular biology, electrophysiology, and senescence pathways.”
Title: Aging impairs the neurovascular interface in the heart
Authors: Julian U. G. Wagner, Lukas S. Tombor, Pedro Felipe Malacarne, Lisa-Maria Kettenhausen, Josefine Panthel, Haris Kujundzic, Nivethitha Manickam, Katja Schmitz, Maria Cipca, Kathrin A. Stilz, Ariane Fischer, Marion Muhly-Reinholz, Wesley T. Abplanalp, David John, Sarajo K. Mohanta, Christian Weber, Andreas J. R. Habenicht, Giulia K. Buchmann, Stephan Angendohr, Ehsan Amin, Katharina Scherschel, Nikolaj Klöcker, Malte Kelm, Dominik Schüttler, Sebastian Clauss, Stefan Günther, Thomas Boettger, Thomas Braun, Christian Bär, Minh-Duc Pham, Jaya Krishnan, Susanne Hille, Oliver J. Müller, Tarik Bozoglu, Christian Kupatt, Eleonora Nardini, Selma Osmanagic-Myers, Christian Meyer, Andreas M. Zeiher, Ralf P. Brandes, Guillermo Luxán, Stefanie Dimmeler
Read the Full Article on Science
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