Abhishek Jain: Vessel-on-a-Chip – Exploring Viral-Induced Endothelial Dysfunction
Abhishek Jain, Associate Professor of Biomedical Engineering, Medical Physiology and Cardiovascular Sciences at Texas A and M University College of Engineering, shared a post on LinkedIn about a recent article he and his colleagues co-authored, published in Journal of Thrombosis and Haemostasis, adding:
“Our work is on the cover of this month’s first issue of Journal of Thrombosis and Haemostasis (JTH)
First authored by my grad student Sreelakshmy Suresh at Texas A and M University Department of Biomedical Engineering, the cover describes her work on demonstrating an ‘Endothelialized vessel-chip platform for modeling SARS-CoV-2 infection–induced endothelial dysfunction’ with support from our UG scholar mentee Rebecca John and in collaboration with Dr. John Connor and Dr. John Cooke.
Also, the publication is promoted via an excellent commentary by Dr. Susan Shea and Dr. Kimberly Thomas, titled, ‘Going with the flow: a new current in viral infection–induced thrombosis’.
I loved their concluding para that states:
‘The Tide is Turning
Suresh et al. demonstrate that shear stress reshapes arterial endothelial responses to viral and inflammatory injury, highlighting the value of vessel-on-a-chip and organ-on-a-chip systems for mechanistic investigation.
The next generation of models should build upon this foundation by incorporating the cellular, extracellular, and hematologic complexity of the vascular niche.
As these model systems continue to evolve, they hold promise not only for better understanding viral-induced endotheliopathy but also for broader applications across thromboinflammatory disease, precision medicine, and therapeutic discovery.’ ”
Title: Shear cytokine crosstalk is a determinant of SARS-CoV-2–induced endothelial pathophysiology and thrombosis in human vessel chips
Authors: Sreelakshmy Suresh, Rebecca John, John P. Cooke, John H. Connor, Abhishek Jain
Stay updated with Hemostasis Today.
-
Nov 4, 2026, 10:11Balancing Thrombosis and Bleeding in Acute Leukemia – Seminars in Thrombosis and Hemostasis
-
Nov 4, 2026, 10:00Harmonizing Bleeding Outcomes in Hemophilia – JTH
-
Nov 4, 2026, 07:38Augustina Isioma Ikusemoro: Advancing Transfusion Medicine Through Innovation and Collaboration
-
Nov 4, 2026, 07:35How to Manage Hemoglobin SC Disease Across the Lifespan? – EHA
-
Nov 4, 2026, 07:14Marc Carrier: Navigating Complex Thrombosis Decisions
-
Nov 4, 2026, 07:06Armghan Ans: Beyond 24 Hours – Can Thrombectomy Still Benefit Stroke Patients?
-
Nov 4, 2026, 03:51Riana Gjeta: Sharing Research on Blood Donor Safety in the Balkans
-
Nov 4, 2026, 03:48Umberto Pensato: World Stroke Congress – Science, Collaboration, and Recognition
-
Nov 4, 2026, 03:41Alejandro González Veliz: Understanding and Managing Stent Underexpansion