Akshat Jain: Transforming Sickle Cell Care With Practical Apheresis Frameworks
Akshat Jain, Hematology Pediatric Workforce Task Force at American Society of Hematology, shared a post on LinkedIn about a recent article he and his colleagues co-authored, published in Therapeutic Apheresis and Dialysis, adding:
“Presenting out latest research in Sickle Cell Disease methodology and innovation simplifying first truly explicit, transparent, evidence-graded framework, for apheresis indications and strategies.
The paper’s importance is that it helped turn sickle cell care from fragmented expert opinion into a clearer guideline process that others can adopt or adapt.
First-time guideline implications:
For the first time, we clearly set out concrete standards for cerebrovascular care in SCD, including annual transcranial Doppler screening for children with HbSS/HbSβ0 thalassemia, transfusion-based stroke prevention in higher-income settings, hydroxyurea as an alternative in lower-resource settings, urgent transfusion for acute neurologic deficits, and MRI screening for silent cerebral infarcts.
The paper’s broader implication is that guideline development in SCD should not wait for perfect evidence; it should use the best available evidence plus structured expert judgment and patient priorities to create actionable care pathways.
Practical takeaways
The paper’s importance is that it helped turn sickle cell care from fragmented expert opinion into a clearer guideline process that others can adopt or adapt.”
Title: Red Blood Cell Exchange in Sickle Cell Disease Care: A Comprehensive Review
Authors: Mahtab Mashayekhi, Mojtaba Akhtari, Akshat Jain, Nasim Salimiaghdam, Amir Abdipour
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