Alan Nurden Shares A Study on Unusual Form of Glanzmann Thrombasthenia
Alan Nurden, Emeritus Research Director at CNRS, shared on LinkedIn:
”A detailed review of published cases of an unusual form of Glanzmann thrombasthenia where gain-of-function mutations in ITGA2B/ITGB3 genes are linked to dysregulation of RhoA activity in megakaryocytes and cytoskeletal-mediated changes in proplatelet formation and platelet release.
Such cases offer a rare insight into integrin biology.”
Read the full article here.
Article: ITGA2B/ITGB3-Related Macrothrombocytopenia Associated With Gain-of-Function Mutations in ITGA2B or ITGB3 Genes
Authors: Jiao Wu, Han Yan, Zijian Li, Yilin Zhu, Ruonan Shao, Honglei Xin, Tongyu Jia, Mengyu Ge, Lu Zhang, Suyu Jiang, Jianhua Mao, Jiansong Huang, Chao Fang, Xiaodong Xi, Xiaofeng Shi
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