Alan Nurden: How Platelets Construct a Thrombus Under Flow
Alan Nurden, Emeritus Research Director at CNRS, Co-Founder of the French National Reference Centre for Inherited Platelet Disorders (CRPP), shared a post on LinkedIn about a recent article by Robert H. Lee et al., published in Blood, adding:
”This short communication in Blood from Robert Lee and his colleagues contains a wealth of information on how platelets construct a thrombus under flow.
Combining studies on human hypofibrinogenemia with up-to-date mouse models that reproduce the disease state and/or an altered Fg αC region function, they concluded that the latter regulated arterial thrombosis under hypofibrinogenemic conditions.
More generally, they showed that fibrin-dependent thrombus construction involved both GPVI dependent and independent pathways.
Given that the ISTH Subcommittee on Health and Disease is currently surveying the very rare occurrence of arterial thrombosis in patients with Glanzmann thrombasthenia, themselves already protected by the absence of alphaIIbbeta3 (or with nonfunctional alphaIIbbeta3), looking at the fibrinogen involvement in their rare thrombotic events (both arterial and venous) may well offer some clues.
It is amazing how such natural pathophysiological variants selectively affecting one or more aspects of thrombus formation, either platelet borne or affecting coagulation pathways, are providing essential information towards the construction of therapies better able to combat cardiovascular disease in the general population.”
Title: The fibrinogen αC region promotes arterial thrombosis in the context of hypofibrinogenemia
Authors: Robert H. Lee, Francesca Ferraresso, Alexander Couzens, Angelica Taylor Jameson, Haley Elizabeth Hanes, Alessandro Casini, Marguerite Neerman-Arbez, Bernhard Nieswandt, Christian J. Kastrup, Wolfgang Bergmeier, Matthew J. Flick, Woosuk Steve Hu
Stay updated on all scientific advances with Hemostasis Today.
-
Aug 11, 2026, 11:04Wolfgang Miesbach: The Critical Need for Tailored Dosing in VWD
-
Aug 11, 2026, 08:20Hasan Abbas Zaheer: Strengthening Universal Access to Safe Blood in Pakistan
-
Aug 11, 2026, 08:07Nicola Pozzi: Advancing Hemostasis Through Scientific Collaboration at Hemostasis GRC
-
Aug 11, 2026, 07:50When Access to Care Changes Everything – WFH
-
Aug 11, 2026, 07:41Kevin Land: How Cellular Therapy Is Changing Transfusion Medicine
-
Aug 11, 2026, 07:35Kuldeep Singh Bhadauria: Building the Future of Hemophilia Care in India
-
Aug 11, 2026, 07:28Archil Jaliashvili: When Every Minute Matters Time Becomes a Therapy
-
Aug 11, 2026, 07:05Mavis Agnes Kisakye: Building Sustainable Transition Pathways in Hemophilia Care
-
Aug 11, 2026, 06:48Rishdha Roshad: What Happens to the Brain During Cardiopulmonary Bypass?