Alfonso Rodriguez Espada/LinkedIn
Sep 20, 2025, 16:20
Alfonso Rodriguez Espada Validates FXII as a Safe Antithrombotic Target
Alfonso Rodriguez Espada, Postdoctoral Fellow at BIDMC and Broad Institute of Harvard and MIT, shared a post on LinkedIn:
“We showed that heterozygous rare FXII variant carriers are protected against venous thromboembolism (VTE) using high confidence loss-of-function variants from the UK Biobank and NIH All of Us Program while also showing that these mutations are not associated with bleeding or sepsis as speculated in previous reports. Data was validated in vivo using MGB blood samples and mice to further evaluate thrombin generation/activity. This data further pushes FXII as a potential drug target that could prevent VTE in a safe and effective way!”
Read more here.
Stay updated with Hemostasis Today.
-
Nov 14, 2025, 11:58Marilena Vrana: Can Public-only Blood Collection Systems Meet the Growing Patient Need for PDMs?
-
Nov 14, 2025, 11:48Cedric Hermans Shares the 1st Illustrated Review Dedicated to Hemophilia B
-
Nov 14, 2025, 10:28Valance Washington: Proud to Share Our Lab’s Latest Publication in Platelets Journal
-
Nov 14, 2025, 10:18Sripal Bangalore and Ajay Kirtane on TUXEDO-2 Comparison Focusing on Diabetic Patients
-
Nov 14, 2025, 10:11Ashley Lawrenson on Her Coagulation Journey Using Automation With the HemoCell and HemoHub
-
Nov 14, 2025, 10:05Kingsley Wheaton: A Year Ago, Omni Was an Idea – Today, It’s a Movement!
-
Nov 14, 2025, 09:58Rucha Patil Takes The National DHR-ICMR Gold Award for Best Technology
-
Nov 14, 2025, 09:48Caitlin Raymond on ”The Plasma Chasers”
-
Nov 14, 2025, 09:42Erin VanDyke on Why They Do In-person Site Visits for NBCA Centers of Excellence Designation!