Alfonso Rodriguez Espada/LinkedIn
Sep 20, 2025, 16:20
Alfonso Rodriguez Espada Validates FXII as a Safe Antithrombotic Target
Alfonso Rodriguez Espada, Postdoctoral Fellow at BIDMC and Broad Institute of Harvard and MIT, shared a post on LinkedIn:
“We showed that heterozygous rare FXII variant carriers are protected against venous thromboembolism (VTE) using high confidence loss-of-function variants from the UK Biobank and NIH All of Us Program while also showing that these mutations are not associated with bleeding or sepsis as speculated in previous reports. Data was validated in vivo using MGB blood samples and mice to further evaluate thrombin generation/activity. This data further pushes FXII as a potential drug target that could prevent VTE in a safe and effective way!”
Read more here.
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