Amro Al-Manasrah: Coronary Reperfusion Injury Beyond Large-Vessel Occlusion
Amro Al-Manasrah, Surgeon, Allumni of Hebron University, shared on LinkedIn about a recent article by Joanne L. Mitchell et al, published in Basic Research in Cardiology, adding:
”Recently read a preclinical study comparing anti-platelet and anti-thrombin strategies in ischemia–reperfusion injury of the coronary microcirculation in both healthy and diabetic models.
The study highlights that myocardial injury after reperfusion is not only driven by large-vessel thrombosis, but also by microvascular dysfunction involving platelets, fibrin, and inflammatory cell recruitment.
Importantly, it emphasizes that in metabolic disease such as diabetes, microcirculatory injury becomes less responsive to standard antithrombotic strategies, underscoring the complexity of reperfusion injury beyond epicardial artery reopening.
A valuable insight into the evolving concept of ‘thrombo-inflammation’ in acute myocardial infarction.”
Title: Comparing anti-platelet and anti-thrombin therapies in the ischaemia–reperfusion injured coronary microcirculation of healthy and diabetic mice
Authors: Joanne L. Mitchell, Juma El-Awaisi, Dean Kavanagh, Bernhard Nieswandt, Robert F. Storey, Neena Kalia
Stay updated on all scientific advances with Hemostasis Today.
-
Aug 13, 2026, 18:39Lukas Röthlisberger: Real-World Evidence on Effectiveness and Safety of Rivaroxaban in Children
-
Aug 13, 2026, 18:36Soner Yilmaz: Blood Safety in Türkiye Through More Than 22.5 Million Blood Donations
-
Aug 13, 2026, 18:31Muthukumarasamy Raja: FDA Approval of EZPLAZ Marks a Breakthrough in Emergency Plasma Care
-
Aug 13, 2026, 18:29Peter Zdziarski: Protecting Our Community While Creating a Future Where We Are No Longer Needed
-
Aug 13, 2026, 18:29Morgan E Amos: Thrilled to Receive the Student Research Award From HTRS
-
Aug 13, 2026, 16:38Sheharyar Raza: Plasma Exchange in Multiple Sclerosis
-
Aug 13, 2026, 16:31Juan Manuel Cisneros Carrasco: The True Cost of Blood Donation
-
Aug 13, 2026, 16:25Connie Montgomery: Bridging the Gap Between Patients, Culture and Clinical Trials
-
Aug 13, 2026, 16:16Isabella Presch: A New AI Approach to Protein Engineering