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Daniel Lorenzatti: EAT is not Just a Bystander but Also a Great Modifiable Therapeutic Target
Daniel Lorenzatti, Annalisa Filtz, Leandro Slipczuk/LinkedIn
Mar 18, 2026, 16:05

Daniel Lorenzatti: EAT is not Just a Bystander but Also a Great Modifiable Therapeutic Target

Daniel Lorenzatti, Associate Research Scientist at Montefiore Health System and Cardiologist at Hospital Universitari de Vic, shared a post on LinkedIn about a recent article he and his colleagues co-authored:

“Excited to share our latest research published in JACC: Cardiovascular Imaging!

‘Epicardial Adipose Tissue, Coronary Plaque Progression, and Major Adverse Cardiovascular Events: A Multicenter Study’

From the PARADIGM (Progression of Atherosclerotic Plaque Determined by Computed Tomographic Angiography Imaging) registry – 773 patients using serial coronary CTA over a median 8-year follow-up.

  • Higher EAT volume (EATv) is independently associated with CAD.
  • EATv predicts both plaque progression (PP) and rapid plaque progression (RPP) – independent of traditional CV risk factors
  • Noncalcified plaque showed nearly 7 times greater progression in the highest vs. lowest EATv tertile
  • Patients with PP and RPP had significantly worse 10 – year MACE-free survival (log-rank P equales 0.003 and Pis is lower than 0.001)

EAT quantification – already obtainable from a standard coronary CTA acquisition – can refine risk stratification and identify patients who may benefit from earlier or more intensive preventive therapy.

EAT is not just a bystander; it may be a modifiable therapeutic target.

Proud to work alongside Annalisa Filtz under the guidance of Leandro Slipczuk in this multicenter effort.

Thanks to all the co – authors and specially to the Montefiore Health System incredible team!”

Title: Epicardial Adipose Tissue, Coronary Plaque Progression, and Major Adverse Cardiovascular Events: A Multicenter Study

Authors: Annalisa Filtz, Daniel Lorenzatti, Andrea Scotti, Kirtipal Bhatia, Felipe Contreras Yametti, Franco J. Cossettini, Hyuk-Jae Chang, Sang-Eun Lee, Piotr J. Slomka, Daniel S. Berman, Deepak L. Bhatt, Fay Y. Lin, Damini Dey, Leslee J. Shaw, Leandro Slipczuk

Read Full Article on JACC

Daniel Lorenzatti

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Andrea Scotti Annalisa Filtz Damini Dey Daniel Lorenzatti Daniel S. Berman Deepak L Bhatt EAT Epicardial Adipose Tissue Fay Y. Lin Felipe Contreras Yametti Franco J. Cossettini Health Hematology Hemostasis Hemostasis News Hemostasis Today Hyuk-Jae Chang JACC Kirtipal Bhatia Leandro Slipczuk Leslee J Shaw Medicine Montefiore Health System PARADIGM Piotr J. Slomka Sang-Eun Lee
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