Daniel Lorenzatti: EAT is not Just a Bystander but Also a Great Modifiable Therapeutic Target
Daniel Lorenzatti, Associate Research Scientist at Montefiore Health System and Cardiologist at Hospital Universitari de Vic, shared a post on LinkedIn about a recent article he and his colleagues co-authored:
“Excited to share our latest research published in JACC: Cardiovascular Imaging!
‘Epicardial Adipose Tissue, Coronary Plaque Progression, and Major Adverse Cardiovascular Events: A Multicenter Study’
From the PARADIGM (Progression of Atherosclerotic Plaque Determined by Computed Tomographic Angiography Imaging) registry – 773 patients using serial coronary CTA over a median 8-year follow-up.
- Higher EAT volume (EATv) is independently associated with CAD.
- EATv predicts both plaque progression (PP) and rapid plaque progression (RPP) – independent of traditional CV risk factors
- Noncalcified plaque showed nearly 7 times greater progression in the highest vs. lowest EATv tertile
- Patients with PP and RPP had significantly worse 10 – year MACE-free survival (log-rank P equales 0.003 and Pis is lower than 0.001)
EAT quantification – already obtainable from a standard coronary CTA acquisition – can refine risk stratification and identify patients who may benefit from earlier or more intensive preventive therapy.
EAT is not just a bystander; it may be a modifiable therapeutic target.
Proud to work alongside Annalisa Filtz under the guidance of Leandro Slipczuk in this multicenter effort.
Thanks to all the co – authors and specially to the Montefiore Health System incredible team!”
Title: Epicardial Adipose Tissue, Coronary Plaque Progression, and Major Adverse Cardiovascular Events: A Multicenter Study
Authors: Annalisa Filtz, Daniel Lorenzatti, Andrea Scotti, Kirtipal Bhatia, Felipe Contreras Yametti, Franco J. Cossettini, Hyuk-Jae Chang, Sang-Eun Lee, Piotr J. Slomka, Daniel S. Berman, Deepak L. Bhatt, Fay Y. Lin, Damini Dey, Leslee J. Shaw, Leandro Slipczuk
Read Full Article on JACC
Stay updated on Hemostasis Today.
-
Apr 16, 2026, 14:05Saleh Shamse Basha: When Platelet Counts Mislead, The PLT-F Becomes Critical
-
Apr 16, 2026, 13:44Maha Othman: Celebrating National Medical Laboratory Week in Canada
-
Apr 16, 2026, 13:42Megan Adediran: How Much of What You Know About Hemophilia Is True?
-
Apr 16, 2026, 13:35Priya Singh: How to Write the Discussion of a Research Paper
-
Apr 16, 2026, 13:14Veronica Sanchez: Blood Pressure Categories for Individuals Who Are Pregnant
-
Apr 16, 2026, 13:07Abdul Mannan: Acute Anaphylactic Reaction During Blood Transfusion
-
Apr 16, 2026, 09:41Wolfgang Miesbach: Adeno-Associated Virus Neutralizing Antibodies and Their Clinical Impact on Gene Therapy
-
Apr 16, 2026, 09:33Jeyaraj Pandian: Low-Cost Stroke Rehabilitation Technologies at MENA-VINM 2026
-
Apr 16, 2026, 09:21Aurore Ughetto: The Hemocompatibility Burden of Micro-Axial Flow Pump Support