Daniel Victor Ortigoza: Apixaban Shows Lower Bleeding Risk than Rivaroxaban in Acute VTE
Daniel Victor Ortigoza, 2nd Vice President of the Cardio-Oncology Committee at the Argentine Federation of Cardiology and President of the Arrhythmias and Electrophysiology Committee of the Argentine Federation of Cardiology, shared a post on LinkedIn about a recent article by Lana A. Castellucci et al, published in The New England Journal of Medicine։
”Bleeding Risk with Apixaban vs. Rivaroxaban in Acute Venous Thromboembolism
Patients with DVT or PE were randomly assigned in a 1:1 ratio to rivaroxaban 15 mg twice daily for 21 days, apixaban 20 mg/day or apixaban 10 mg twice daily for 7 days, followed by apixaban 5 mg twice daily, both groups for 3 months.
The primary outcome (PO) was clinically relevant bleeding (CRB), a composite of clinically relevant non-major bleeding (CRNMB) or clinically relevant non-major bleeding according to the ISTH, and major bleeding (MB). The secondary outcomes (SO) were the individual components of the primary PE: recurrent DVT/PE.
CRB was observed in 3.3% with Apixaban versus 7.1% with Rivaroxaban (Relative Risk: 0.46; 95% CI, 0.33 to 0.65; P<0.001). MB 0.4% versus 2.4%; Relative Risk: 0.16; 95% CI, 0.06 to 0.40.
The percentage of DVT/PE recurrence was similar in the two treatment groups at 3 months
These data cannot be extrapolated to atrial fibrillation; the COBBRA-AF study on atrial fibrillation is currently underway.”
Title: Bleeding Risk with Apixaban vs. Rivaroxaban in Acute Venous Thromboembolism
Authors: Lana A. Castellucci, Vivien M. Chen, Michael J. Kovacs, Alejandro Lazo-Langner, Peter Greenstreet, Susan Kahn, Benoit Côté, Sam Schulman, Kerstin de Wit, James Douketis, Deepa Suryanarayan, Tony Wan, Erik Yeo, Genevieve Le Templier, Huyen A. Tran, Abbey Willcox, Helen J. Crowther, Ritam Prasad, Sudeep Shivakumar, Etimbuk Umana, Fionnuala Ni Ainle, Tobias Tritschler, Stefano Barco, Jean-Philippe Galanaud, Marc Blondon, Lisa Baumann Kreuziger, Susan Solymoss, Clive Kearon, Erin Thomas, Tim Ramsay, Gregoire Le Gal, Marc Rodger
Read the Full Article on The New England Journal of Medicine
Stay updated on all scientific advances with Hemostasis Today.
-
May 6, 2026, 10:40Ifeanyichukwu Ifechidere: Why INR Can Be Dangerously Misleading
-
May 6, 2026, 02:58Limiaa Babikir: What Is Polyspecific DAT?
-
May 6, 2026, 02:47Karen Rollinson: Connecting with so Many Families and Advocates at HFA 2026
-
May 6, 2026, 02:38Moustafa Abdou: Is the Bone Marrow Examination Still the ‘Gold Standard’?
-
May 6, 2026, 02:23Khaled Musallam: When the Worlds of Thalassemia and Hemophilia Converge
-
May 6, 2026, 02:12Caitlin Raymond: How STOP-BABESIOSIS Just Rewrote 40 Years of Practice
-
May 5, 2026, 16:28Nikolay Novitski: A New Era in Cardiovascular Prevention
-
May 5, 2026, 16:23Satyam Arora: Best Abstract Award in Pediatric Apheresis at ASFA 2026 Congress
-
May 5, 2026, 16:17Hannah Omunakwe: Your Sick Child Has a Clot. Did You See That Coming?