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David Murdock: Identifying High-Risk Variants of Uncertain Significance in Aortopathy Genes
David Murdock/LinkedIn
May 15, 2026, 16:35

David Murdock: Identifying High-Risk Variants of Uncertain Significance in Aortopathy Genes

David Murdock, Assistant Professor at The University of Texas Health Science Center at Houston, shared a post on LinkedIn about a recent article he and his colleagues co-authored, published in Genetics in Medicine, adding:

“Excited to share our recent publication in Genetics in Medicine on identifying high-risk variants of uncertain significance (VUS) in aortopathy genes.

Using bioinformatic tools, we show how select VUS are strongly associated with increased risk of aortic dissection, helping move genetic findings closer to clinical action.”

Title: Using bioinformatic tools to identify high-risk variants of uncertain significance in aortopathy genes that increase aortic dissection risk

Authors: John DePaolo, Dong-chuan Guo, David R. Murdock, Alana C. Cecchi, Scott A. LeMaire, Hu Ying Shen, Anthony L. Estrera, Hazim J. Safi, Joseph S. Coselli, Josh Smith, Michael J. Bamshad, Scott Damrauer, Dianna M. Milewicz

David Murdock

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Alana C. Cecchi Anthony L. Estrera David Murdock David R. Murdock Dianna M. Milewicz Dong-chuan Guo Genetics in Medicine Hazim J. Safi Health Hematology Hemostasis Hemostasis News Hemostasis Today Hu Ying Shen John DePaolo Joseph S. Coselli Josh Smith Medicine Michael J. Bamshad Scott A. LeMaire Scott Damrauer variants of uncertain significance VUS
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