Federico Ravaioli: 40 kPa Spleen Stiffness May Help Avoid Endoscopy in Chronic PVT
Federico Ravaioli, Tenure-Track Researcher (Law 79/2022) at the University of Bologna, shared a post on LinkedIn about a recent article he and his colleagues co-authored, published in Journal of Hepatology, adding:
“SSM 40 kPa may be the number to remember also in chronic portal vein thrombosis.
Our new multicentre study in the Journal of Hepatology suggests that spleen stiffness measurement by VCTE less than or equal to 40 kPa can identify patients with chronic portal vein thrombosis without cirrhosis who have a very low probability of high-risk varices.
In 346 patients from 16 VALDIG centres:
- NPV: 97% in the derivation cohort
- NPV: 96% in the validation cohort
- 41–43% of screening endoscopies potentially spared
- Less than or equal to 5% of high-risk varices missed
This is particularly relevant because, unlike in cirrhosis, liver stiffness cut-offs cannot simply be transferred to chronic PVT, and current strategies still rely heavily on repeated endoscopic screening.
A simple non-invasive measurement may therefore help us better select who really needs endoscopy.
Very happy to have contributed to this EASL the home of Hepatology VALDIG collaborative study, now published in the Journal of Hepatology.”
Title: Spleen stiffness measurement rules out high-risk varices in patients with chronic portal vein thrombosis without cirrhosis
Authors: Lucile Moga, Audrey Payancé, Luis Téllez, Dario Saltini, Lucia Giuli, Asunción Ojeda, Elton Dajti, Ekaterina Liusina, Francisco Capinha, Dominik Bettinger, Teresa Monllor-Nunell, Arathi Venu, Gowripriya Nair, Laure Elkrief, Joel Silva, Magdalena Meszaros, Markus Peck-Radosavljevic, Sara Reinartz Groba, Christiane Stern, Laurent Castéra, Michael Praktiknjo, Boris Guiu, Arun Valsan, José Ferrusquía-Acosta, Carlos Noronha Ferreira, Maria Nadinskaya, Federico Ravaioli, Fanny Turon, Francesco Santopaolo, Filippo Schepis, Agustin Albillos, Pierre-Emmanuel Rautou, Aurélie Plessier
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