Filipe Gonçalves: Are DOACs Truly Pharmacokinetically Predictable or Simply Pharmacodynamically Forgiving?
Filipe Gonçalves, Docente at NOVA Medical School, shared a post on LinkedIn about a recent article by Joseph R. Shaw and Jack Ansell, published in Journal of Thrombosis and Haemostasis (JTH), adding:
”Are DOACs truly pharmacokinetically predictable or simply pharmacodynamically forgiving?
This article challenges a central assumption behind fixed-dose DOAC therapy.
Drug concentrations may vary considerably, while clinical effectiveness may persist because the pharmacodynamic response remains acceptable across a relatively broad exposure range.
It also highlights an important distinction between measuring drug concentration and measuring anticoagulant effect.
It also reminds us that commonly used thresholds such as 30 or 50 ng/mL are pragmatic decision cut-offs, not biologically validated safety boundaries.
A relevant perspective for pharmacology, laboratory medicine and urgent clinical decision-making.”
Title: A light in the dark—reframing direct oral anticoagulant pharmacokinetics and pharmacodynamics for near-patient decision-making
Authors: Joseph R. Shaw, Jack Ansell
Stay updated on all scientific advances with Hemostasis Today.
-
Aug 6, 2026, 18:04Wolfgang Miesbach: Base Editing Expands Therapeutic Targets for Hemophilia B
-
Aug 6, 2026, 18:03Identifing Gaps in How IDA is Recognised and Managed in Children – ISBT
-
Aug 6, 2026, 18:03Expanding Access to Care for People With Hemophilia in Côte d’Ivoire – WFH
-
Aug 6, 2026, 18:00Kavita Vinod Paul: Transforming Lives Through Comprehensive Care and Community Leadership
-
Aug 6, 2026, 17:59BSH Good Practice Paper on Multidisciplinary Hematology and Gynecology Care – British Journal of Haematology
-
Aug 6, 2026, 17:38Cameron Cook: How Cost-Effective Is Evolocumab for Patients at High Cardiovascular Risk?
-
Aug 6, 2026, 15:53Pall T. Onundarson: Frail Elderly Korean Atrial Fibrillation Patients Do Worse If Switched to DOACs in a Nationwide Observational Study
-
Aug 6, 2026, 15:46Zain Khalpey: Left Atrial Appendage Closure vs Oral Anticoagulation in Atrial Fibrillation
-
Aug 6, 2026, 15:25Mohd Ashhad: Cryoprecipitate – A Small Blood Component with a Big Clinical Role