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The Inflammasome Pathway as a Key Positive Regulator of HIT Pathology – JTH
First author of the article - James Michael/LinkedIn
May 9, 2026, 14:30

The Inflammasome Pathway as a Key Positive Regulator of HIT Pathology – JTH

Journal of Thrombosis and Haemostasis (JTH) shared on LinkedIn about a recent article by James Michael et al, adding:

”Heparin-Induced Thrombocytopenia Immune Complexes Activate the Inflammasome Pathway in a Complement-Dependent Manner

This study demonstrates that HIT immune complexes trigger NLRP3 inflammasome activation and IL-1β secretion via FcγRIIA and complement-dependent signaling in both human blood and transgenic mouse models, identifying the inflammasome pathway as a key positive regulator of HIT pathology. ”

Title: Heparin-induced thrombocytopenia immune complexes activate the inflammasome pathway in a complement-dependent manner

Authors: James Michael, Sanjay Khandelwal, Antonios Tawk, MD, MSc, Sophia Lazar, Christopher Garren Hester, Trenton G. Hiatt, Gowthami M. Arepally, Steven McKenzie

The Inflammasome Pathway as a Key Positive Regulator of HIT Pathology - JTH

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Antonios Tawk Christopher Garren Hester Gowthami M. Arepally Health Hematology Hemostasis Hemostasis News Hemostasis Today Heparin HIT James Michael MD Medicine MSC Sanjay Khandelwal Sophia Lazar Steven McKenzie thrombocytopenia thrombosis Trenton G. Hiatt
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