The Inflammasome Pathway as a Key Positive Regulator of HIT Pathology – JTH
Journal of Thrombosis and Haemostasis (JTH) shared on LinkedIn about a recent article by James Michael et al, adding:
”Heparin-Induced Thrombocytopenia Immune Complexes Activate the Inflammasome Pathway in a Complement-Dependent Manner
This study demonstrates that HIT immune complexes trigger NLRP3 inflammasome activation and IL-1β secretion via FcγRIIA and complement-dependent signaling in both human blood and transgenic mouse models, identifying the inflammasome pathway as a key positive regulator of HIT pathology. ”
Title: Heparin-induced thrombocytopenia immune complexes activate the inflammasome pathway in a complement-dependent manner
Authors: James Michael, Sanjay Khandelwal, Antonios Tawk, MD, MSc, Sophia Lazar, Christopher Garren Hester, Trenton G. Hiatt, Gowthami M. Arepally, Steven McKenzie
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