Ilkin Aygun Soyalp: Novel Substrate Recognition Broadens the Biological Role of DPF-3
Ilkin Aygun Soyalp, Postdoctoral Researcher at Center for Advanced Technologies, shared a post on LinkedIn about a recent article she and her colleagues co-authored, published in EMBO Reports, adding:
“Proteases are essential regulators of cellular homeostasis.
In our latest paper, we broaden the understanding of substrate specificity and physiological relevance of DPF-3, a member of the DPPIV family proteases, combining unbiased proteomics with functional validation.
We identify MEP-1 as a DPF-3 substrate cleaved after a threonine residue, the first physiological DPPIV-family substrate with a noncanonical P1 residue.
Preventing this cleavage destabilizes MEP-1 and impairs reproductive development, demonstrating that this processing is functionally essential.
A great collaboration between Dr. Rajani Gudipatti’s group (Center for Advanced Technologies, Adam Mickiewicz University) and Dr. Helge Großhans, together with all the co-authors at FMI Basel!”
Title: Cleavage of MEP-1 by DPF-3 reveals novel substrate specificity and its impact on reproductive fitness
Authors: Ilkin Aygün, Afzal Amanullah, Jan Seebacher, Daniel Hess, Charlotte Soneson, Ankit Roy, Helge Großhans, Rajani Kanth Gudipati
Stay updated on all scientific advances with Hemostasis Today.
-
Jun 22, 2026, 14:29Swarnava Roy: Linking Angiotensin Signaling to Oxidative Stress and Organ Damage in Sickle Cell Anemia
-
Jun 22, 2026, 14:14Nicolò Vianini: New Evidence Confirms Bone Marrow as the Primary Site of Thrombopoiesis
-
Jun 22, 2026, 14:11Param Darpan Sheth: Revealing the Evolving Burden of MI and Heart Failure Mortality in the US
-
Jun 22, 2026, 13:56Eiman Emran: The Hematologic Consequences of Heavy Menstrual Bleeding
-
Jun 22, 2026, 13:47Isaac Okello: A Unified Voice for Sickle Cell Disease in Uganda
-
Jun 22, 2026, 13:40Anupama Krishnamoorthi: Inspiring the Next Generation of Haematologists
-
Jun 22, 2026, 13:39Heghine Khachatryan: The Inflammatory Engine Behind Venous Thrombosis
-
Jun 22, 2026, 13:35Aryabhatta Sadhu: Which Part of Haemostasis Has Failed First?
-
Jun 22, 2026, 13:17Maha Assadoon: Can IV Iron Be Safely Used During Infection?