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Irina Portier: How Heme-Driven Platelet Signaling Worsens Malaria Neuropathogenesis
May 16, 2026, 14:18

Irina Portier: How Heme-Driven Platelet Signaling Worsens Malaria Neuropathogenesis

Irina Portier, Postdoctoral Researcher at Washington University in St. Louis, shared a post on LinkedIn about a recent article she and her colleagues co-authored, published in Blood, adding:

“How does platelet mTOR contribute to cerebral malaria, and how does heme trigger these events?

I’m excited to share that our latest paper addressing these questions is now published in Blood.

Huge thanks to my mentors and collaborators Robert Campbell, Matthew Rondina, Frederik Denorme, Izabella Andrianova, Paul Sigala, Tracey Lamb, Neal Tolley, Yasuhiro Kosaka, Guy Zimmerman, Hugo Castro-Faria-Neto and Craig Morrell for their support and contributions.

We are especially honored to have our work featured on the cover and highlighted in the Blood podcast.

Also check out the insightful commentary accompanying our article.”

Title: Heme-induced ITAM signaling exacerbates malaria-associated neuropathogenesis through activation of platelet mTOR

Authors: Irina Portier, Frederik Denorme, Neal D. Tolley, Yasuhiro Kosaka, Izabella Andrianova, Paul A. Sigala, Tracey J. Lamb, Guy A. Zimmerman, Hugo C. Castro-Faria-Neto, Craig N. Morrell, Matthew T. Rondina, Robert A. Campbell

Irina Portier: How Heme-Driven Platelet Signaling Worsens Malaria Neuropathogenesis

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