Jasmin Hefendehl: Ischemic Stroke Reveals a Protective Microglial Response in Alzheimer’s Pathology
Jasmin Hefendehl, Professor at the Institute for Cell Biology an Neuroscience at Goethe University Frankfurt, shared on LinkedIn about a recent article she and her colleagues co-authored, published in Journal of Neuroinflammation, adding:
”Thrilled to share our new paper featuring my favorite cell type – Microglia, just published in the Journal of Neuroinflammation: ‘Ischemic injury triggers a protective microglial phenotype in models of Aβ pathology’.
Here’s what we found: when ischemic stroke occurs in the context of Alzheimer’s pathology, instead of simply amplifying the canonical disease-associated microglial response, the peri-infarct microenvironment triggers something qualitatively different.
Microglia upregulate ApoE, ramp up lipid handling, and compact amyloid-beta plaques into dense, relatively inert structures with less neurotoxic halo and fewer dystrophic neurites.
These peri-infarct plaques are strikingly similar to those seen in cognitively resilient Alzheimer’s patients.
Using scRNA-seq, spatial transcriptomics, and confocal Raman microscopy, we show that the microglial compartment retains plasticity, and the right stimulus can unlock a functionally superior response to Aβ.
ApoE emerged as the single gene consistently upregulated across every relevant microglial cluster and every peri-infarct plaque-associated spatial spot.
These findings open the door to pharmacologically recapitulating this protective phenotype.
Huge congratulations to co-first authors Dr. Michael Candlish and Jan Hofmann, and to our whole team of collaborators.”
Title: Ischemic injury triggers a protective microglial phenotype in models of Aβ pathology
Authors: Michael Candlish, Jan Hofmann, Desirée Brösamle, Annika Haessler, Murphy DeMeglio, Angelos Skodras, Georgi Tushev, Eloah S. De Biasi, Stefan Günther, René Wiegandt, Heidi Theis, Elena De Domenico, Nina Sofia Hermann, Peter Breunig, Christina Sauerland, K. Peter R. Nilsson, Marc D. Beyer, Mario Looso, Maike Windbergs, Sigrun Roeber, Jochen Herms, Jonas J. Neher, Andreas G. Chiocchetti, Jasmin K. Hefendehl
Stay updated on all scientific advances with Hemostasis Today.
-
Sep 22, 2026, 15:27Zia Ullah: RBC-Derived Extracellular Vesicles as Potential Biomarkers of Thrombotic Risk in Dengue
-
Sep 22, 2026, 15:01Lesley Van Wyk: What Each Iron Markers Actually Mean
-
Sep 22, 2026, 14:37Chokri Ben Lamine։ Saudi Arabia Leads A New Milestone In Hemophilia A Care
-
Sep 22, 2026, 13:58Giulia Passaniti: Dual Inferior Vena Cava Anatomy in Tetralogy of Fallot
-
Sep 22, 2026, 13:35Michael Miyamoto: Scaling Guideline Based Lipid Management in Community Practice
-
Sep 22, 2026, 13:15Suvro Sankha Datta: Developing Blood Group Genotyping Platform Using a Gold-Oligo
-
Sep 22, 2026, 13:07Caitlin Raymond: The Plasma Chaser in Therapeutic Plasma Exchange
-
Sep 22, 2026, 09:18Shamee Shastry: How Transfusion Medicine Research Is Evolving in India
-
Sep 22, 2026, 09:11Tarique Shahzad Chachar: Why Warfarin Remains the Gold Standard for Mechanical Heart Valves