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Jason Andrade Presents Evidence Supporting Reduced Need for OAC Post-AF Ablation
Jason Andrade/X
Sep 11, 2025, 08:38

Jason Andrade Presents Evidence Supporting Reduced Need for OAC Post-AF Ablation

 

Jason Andrade, Cardiologist at Vancouver Coastal Health, Elite Expert in Atrial Fibrillation, Co-chair of CCS, posted on X:

”In light of the recently published ALONE-AF trial, which tested the hypothesis that OAC discontinuation post ablation was a safe(r) strategy for patients I thought it would be good to review our recently larger meta-analysis   on the topic.

In this analysis we examined 63 RCTs containing 11,161 patients

We found catheter ablation:
– Reduced the risk of stroke by 37% (7 less stroke per 1000 treated patients)
– Reduced the risk of death by 23% (16 less deaths per 1000 treated patients)

In conclusion, this large analysis of multiple RCTs shows that ablation reduces hard cardiovascular outcomes with high certainty.

Thus providing rationale for why OAC may not be necessary post ablation, as the risk of stroke is substantially reduced (eg 1.5% in OPTION, and 0.3-0.8% in ALONE-AF).”

Read the full study here.

Title: Catheter and Surgical Ablation for Atrial Fibrillation: A Systematic Review and Meta-analysis

Authors: Bryce Montané, Shiyang Zhang, Jonathan D. Wolfe, Sabrina Prime, Chongliang Luo, Daniel H. Cooper, Michelle Doering, Carina Blomstrom-Lundqvist, Samer A.M. Nashef, Pavel Osmancik, Jason G. Andrade,   Emanuele Bertaglia, Ratika Parkash, Daniel B. Mark, Jens C. Nielsen, Linda D. Sharples, Brian F. Gage

Jason Andrade Presents Evidence Supporting Reduced Need for OAC Post-AF Ablation Jason Andrade Presents Evidence Supporting Reduced Need for OAC Post-AF Ablation Atrial Fibrillation

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Atrial Fibrillation Brian F. Gage Bryce Montané Cardiology Carina Blomstrom-Lundqvist Catheter Ablation Chongliang Luo Daniel B. Mark Daniel H. Cooper Emanuele Bertaglia Health Hematology Hemostasis Hemostasis Today Jason Andrade Jens C. Nielsen Jonathan D. Wolfe Linda D. Sharples Medicine Michelle Doering OAC Oral Anticoagulation Pavel Osmancik Ratika Parkash Sabrina Prime Samer A.M. Nashef Shiyang Zhang stroke Surgical Ablation thrombosis Vancouver Coastal Health
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