Jim Hoffman: Uncontrolled Neutrophil Activation and NET Release in the Vasculature
Jim Hoffman, Former Technical Advisor at Cygnus Technologies, LLC, posted on LinkedIn:
” ‘We observe extensive spontaneous neutrophil extracellular trap (NET) formation in MIS-C, and we identify neutrophil activation and degranulation signatures. Mechanistically, we determine that SARS-CoV-2 immune complexes are sufficient to trigger NETosis. Our findings suggest that hyperinflammatory presentation during MIS-C could be mechanistically linked to persistent SARS-CoV-2 antigenemia, driven by uncontrolled neutrophil activation and NET release in the vasculature.’ Yonker et al 2022 Neutrophil profiles of pediatric COVID-19 and multisystem inflammatory syndrome in children
Here is a extracorporeal removal therapy developed by https://santersus.com. This therapy is designed to specifically remove and treat the immunothrombotic complications resulting from LC and many other disease triggers worsened by having too many hyperactivated neutrophils/NETs circulating in the blood. Read more here.
Directly targeting the removal of NETs from plasma is proving powerful for the treatment of severe drug-refractory SLE. What about other hyperactivated NETotic-driven diseases like LC PASC/MIS-C or A that display chronic low to intermediate grade NETosis dysregulation?
Your findings of hyperactivated NETosis induction and poor NET clearance are not unique. For more research, visit here.”
Quoting PolyBio Research Foundation’s post:
“PolyBio supports research & treatment for children with Long COVID. This year, a study by our team at Harvard Medical School found that neutrophil immune cells from children with Long Covid were hyperactive and associated with pro-inflammatory pathway signaling.
Circulating spike protein, potentially leaking from SARS-CoV-2 tissue reservoirs, was detected in blood from a subset of children. We are further supporting a clinical trial in Long COVID children, to test if the drug Larazotide can reduce gut barrier permeability, thereby stopping spike leakage into blood.
Learn more about the research that PolyBio is driving forward in our Impact Report”
Get informed with Hemostasis Today.
-
Dec 19, 2025, 06:13Anna Aldehag Reflects on Her 12 Year Leadership in Sweden National Board of Health and Welfare
-
Dec 19, 2025, 05:54Abdul Mannan: APTT Mixing Studies Confuse a Lot of People
-
Dec 18, 2025, 23:14The “Normal” FVIII Level Trap in Females with Haemophilia
-
Dec 18, 2025, 23:11WFH Expands Multidisciplinary Bleeding Disorder Training in Vietnam
-
Dec 18, 2025, 17:13Daria Camilli on EuroBloodNet and EHC Collaboration for Bleeding Disorders
-
Dec 18, 2025, 16:50Marie Cambot on Innovhem’s Quantification of The HbF/HbS Ratio for SCD
-
Dec 18, 2025, 16:26Yogesh Rathod on Hematological Issues and ICU
-
Dec 18, 2025, 16:09Carlos Doti: I’m Reminded Why ASH is Such a Powerful Close to The Year
-
Dec 18, 2025, 15:23Michael Hadley: Well-Timed ACC Statement Just Out in JACC Journals