Jim Hoffman: Uncontrolled Neutrophil Activation and NET Release in the Vasculature
Jim Hoffman, Former Technical Advisor at Cygnus Technologies, LLC, posted on LinkedIn:
” ‘We observe extensive spontaneous neutrophil extracellular trap (NET) formation in MIS-C, and we identify neutrophil activation and degranulation signatures. Mechanistically, we determine that SARS-CoV-2 immune complexes are sufficient to trigger NETosis. Our findings suggest that hyperinflammatory presentation during MIS-C could be mechanistically linked to persistent SARS-CoV-2 antigenemia, driven by uncontrolled neutrophil activation and NET release in the vasculature.’ Yonker et al 2022 Neutrophil profiles of pediatric COVID-19 and multisystem inflammatory syndrome in children
Here is a extracorporeal removal therapy developed by https://santersus.com. This therapy is designed to specifically remove and treat the immunothrombotic complications resulting from LC and many other disease triggers worsened by having too many hyperactivated neutrophils/NETs circulating in the blood. Read more here.
Directly targeting the removal of NETs from plasma is proving powerful for the treatment of severe drug-refractory SLE. What about other hyperactivated NETotic-driven diseases like LC PASC/MIS-C or A that display chronic low to intermediate grade NETosis dysregulation?
Your findings of hyperactivated NETosis induction and poor NET clearance are not unique. For more research, visit here.”
Quoting PolyBio Research Foundation’s post:
“PolyBio supports research & treatment for children with Long COVID. This year, a study by our team at Harvard Medical School found that neutrophil immune cells from children with Long Covid were hyperactive and associated with pro-inflammatory pathway signaling.
Circulating spike protein, potentially leaking from SARS-CoV-2 tissue reservoirs, was detected in blood from a subset of children. We are further supporting a clinical trial in Long COVID children, to test if the drug Larazotide can reduce gut barrier permeability, thereby stopping spike leakage into blood.
Learn more about the research that PolyBio is driving forward in our Impact Report”
Get informed with Hemostasis Today.
-
Feb 23, 2026, 18:13Fight4Hematology Supports Research and Empowers the Next Generation – ASH
-
Feb 23, 2026, 17:59Wolfgang Miesbach: Real-World Evidence of Emicizumab on Joint Outcomes in Hemophilia A
-
Feb 23, 2026, 17:56Shiny K Kajal: The Transfusion Reaction We Often Miss
-
Feb 23, 2026, 17:53Radheshyam Meher: Contributing to the Transfusion Evidence Round-Up for International Childhood Cancer Day 2026
-
Feb 23, 2026, 17:46Mahesan Subramaniam: The Physiological Impact of Anger on Immunity
-
Feb 23, 2026, 17:42Bryan Fry: First Evidence That Bothrops atrox Venom Directly Activates Human Factor VII
-
Feb 23, 2026, 17:34Bastu Odoka: Why Blood Should NOT be Left at the Bedside to ‘Warm’
-
Feb 23, 2026, 17:28Henry Burkitt: Patients Are Challenging How the Medicines Policy System Works in England
-
Feb 23, 2026, 16:50Mutaz Al‑Sabah: Interesting Webinar on FH in Women is Now Available to Watch