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Juha Kotimaa։ New Insights into How APAC Shapes Complement Activation and Inflammation
Juha Kotimaa/LinkedIn; Riitta Lassila/LinkedIn
Apr 27, 2026, 14:32

Juha Kotimaa։ New Insights into How APAC Shapes Complement Activation and Inflammation

Juha Kotimaa, Senior Research Scientist at VTT, shared a post on LinkedIn about a recent article he and his colleagues co-authored, published in Blood Vessels, Thrombosis and Hemostasis:

“Happy to share a study long in the making with Seppo Meri, Riitta Lassila, Mikel Rezola Artero and Annukka Jouppila.

We show an intriguing mechanistical insights into how the dual antiplatelet-anticoagulant APAC modulates complement activation on injured cells – by enhancing C3 opsonization while limiting proinflammatory ”

 

Riitta Lassila, Professor of Coagulation Medicine at University of Helsinki, shared this post, adding:

“Now that the final manuscript is available in bloodVTH.

I am grateful for this collaboration and attention to the impact of coagulation on complement and the regulatory capacity of an antiplatelet and anticoagulant APAC.”

Title: Interactions of dual antiplatelet and anticoagulant with C1q and FH regulate complement activation by injured cells

Authors: Juha Kotimaa, Mikel Artero Rezola, Annukka Jouppila, Riitta Lassila, Seppo Meri

Juha Kotimaa։ New Insights into How APAC Shapes Complement Activation and Inflammation

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Annukka Jouppila anticoagulant Antiplatelet APAC bleeding disorders blood VTH Health Hematology Hemostasis Hemostasis News Hemostasis Today Juha Kotimaa Medicine Mikel Artero Rezola Riitta Lassila Seppo Meri thrombosis
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