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Leonardo Cardoso: Mechanical Thrombectomy Improves Functional Independence, Outcomes and Reduces Mortality
Leonardo Cardoso/LinkedIn
Feb 22, 2026, 07:20

Leonardo Cardoso: Mechanical Thrombectomy Improves Functional Independence, Outcomes and Reduces Mortality

Leonardo Cardoso, Medical Student at Federal University of Minas Gerais, shared on LinkedIn about a recent article he and his colleagues co-authored, adding:

”Mechanical thrombectomy (MT) is a well-established treatment for eligible patients with large-vessel occlusion acute ischemic stroke.

However, its safety and efficacy in elderly patients remain a matter of debate.

In our recently published study in The Neuroradiology Journal, we analyzed data from 15 randomized clinical trials including elderly patients (≥70 years) treated with MT versus standard medical management.

We also explored potential effect modifiers such as stroke severity, anterior versus posterior circulation, use of general anesthesia, time from onset to randomization, country socioeconomic status, infarct size, and imaging selection strategies.

Key findings:

  • MT was associated with higher rates of functional independence and functional recovery at 90 days.
  • Lower rates of severe disability were observed in the thrombectomy group.
  • Mortality was reduced, particularly among patients over 80 years.
  • Benefits were consistent across circulation territories and most subgroup analyses, including large infarcts.

We discuss how these findings integrate with the current literature and contemporary guideline recommendations, while also addressing remaining gaps and future research directions for this growing and clinically complex population.

I would like to sincerely thank my coauthors for this collaboration, Ahmet Günkan and Márcio Yuri Ferreira for their guidance, Professors Panagiotis Papanagiotou and Jean-Claude Baron for their supervision and insights, and Sávio B. for the original study idea.”

Title: Mechanical thrombectomy for elderly stroke patients: An updated systematic review and meta-analysis of randomized clinical trials

Authors: Leonardo Januário Campos Cardoso, Ahmet Günkan, Marcio Yuri Ferreira, Madhav Sambhu, Xiaoyi Gao, Christian Ken Fukunaga, Filipe Virgilio Ribeiro, Anderson Matheus Pereira da Silva, Elison Emanuel Araújo Lima, Ocílio Ribeiro Gonçalves, Ivan Petterson Santana Teixeira, Christian Ferreira, Yafell Serulle, David Stuart Gordon, Panagiotis Papanagiotou, Jean-Claude Baron

Read the Full Article on The Neuroradiology Journal

Leonardo Cardoso: Mechanical Thrombectomy Improves Functional Independence, Outcomes and Reduces Mortality

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Ahmet Günkan Anderson Matheus Pereira da Silva Christian Ferreira Christian Ken Fukunaga David Stuart Gordon Elison Emanuel Araújo Lima Filipe Virgilio Ribeiro Health Hematology Hemostasis Hemostasis News Hemostasis Today Ivan Petterson Santana Teixeira Jean-Claude Baron Leonardo Januário Campos Cardoso Madhav Sambhu Marcio Yuri Ferreira Mechanical thrombectomy Medicine Ocílio Ribeiro Gonçalves Panagiotis Papanagiotou stroke The Neuroradiology Journal thrombosis Xiaoyi Gao Yafell Serulle
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