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Tessa Jaspers and Colleagues on Current Evidence Not Supporting Routine Anti-Xa Monitoring in Use of LMWH
Journal of Thrombosis and Haemostasis (JTH)/LinkedIn
Sep 7, 2025, 17:19

Tessa Jaspers and Colleagues on Current Evidence Not Supporting Routine Anti-Xa Monitoring in Use of LMWH

Journal of Thrombosis and Haemostasis (JTH) shared on LinkedIn:

”A systematic review on anti-Xa monitoring in the therapeutic use of low-molecular-weight heparins

LMWHs are widely used in diverse patient groups (renal impairment, pregnancy, obesity), but the value of anti-Xa monitoring remains unclear.

This systematic review of 48 studies (RCTs and observational) found:

  • Comparable bleeding and VTE rates in monitored vs. unmonitored patients.
  • Frequent dose adjustments in monitored cohorts.
  • Weak or absent correlation between anti-Xa levels and clinical outcomes.

Current evidence does not support routine anti-Xa monitoring for LMWH dose adjustment.”

Read the full paper in JTH.

Article: A systematic review on anti-Xa monitoring in the therapeutic use of low-molecular-weight heparins

Authors: Tessa C. C. Jaspers, P. Christian Remmelzwaal, Eefje P.S. Weersink, Karina Meijer, Nakisa Khorsand

Tessa Jaspers and Colleagues on Current Evidence Not Supporting Routine Anti-Xa Monitoring in Use of LMWH

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anti-Xa Eefje P.S. Weersink Health Hematology Hemostasis Hemostasis Today JTH Karina Meijer LMWH Medicine Nakisa Khorsand Obesity P. Christian Remmelzwaal Pregnancy renal impairment Tessa C.C. Jaspers thrombosis VTE
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