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Science

Melasma Treatment Advances: Non-Ablative Laser and Tranexamic Acid Combination Explained

aidevmd.com

Sep 5, 2025, 14:04

Melasma Treatment Advances: Non-Ablative Laser and Tranexamic Acid Combination Explained

Max Thorne posted on LinkedIn:

“Enhancing Melasma Treatment: Benefits of Non-Ablative Laser and Tranexamic Acid”

Understanding the Study on Melasma Treatment

This study looked at a new way to treat melasma, a skin condition that causes dark patches on the face. It combined two treatments: a non-ablative fractional laser (NAFL) and a topical medication called tranexamic acid (TXA). The goal was to see if this combination works better than using TXA alone.

What Worked?

The combination of NAFL and TXA showed better results in reducing melasma compared to TXA alone right after treatment.

Patients felt more satisfied with the results when using both treatments.

What Didn’t Work?

While there was improvement right after treatment, the benefits did not last long-term. Melasma returned in both groups during follow-ups.

After one and three months, there was no significant difference in results between the two treatment sides.

How Does This Help Patients and Clinics?

For patients, this study suggests that combining NAFL with TXA can provide quick improvements in melasma. However, it also highlights the need for ongoing treatment to maintain results. Clinics can use this information to offer more effective treatment options.

Real-World Opportunities

Clinics can start offering the combination treatment of NAFL and TXA for patients with melasma.

Doctors can educate patients about the potential for short-term improvement and the possibility of recurrence.

Measurable Outcomes to Track

Track changes in melasma severity using a standard scoring system.

Monitor patient satisfaction regularly after treatment.

Keep records of how long the results last before melasma returns.

AI Tools to Consider

Clinics might explore AI tools that can help analyze skin conditions or predict treatment outcomes based on patient data. These tools can assist in personalizing treatment plans.

Step-by-Step Plan for Clinics

Start by training staff on the new treatment combination of NAFL and TXA.

Begin with a small group of patients to monitor results and gather feedback.

Gradually expand the treatment offering based on initial success and patient satisfaction.

Regularly assess and adjust treatment plans based on patient outcomes and feedback.

For more details on the research, you can read the full study here.

Source

Smart Healthcare”

Title: Efficacy of Non-Ablative Fractional Laser Combined With Tranexamic Acid in Melasma Treatment: A Randomized Split-Face Trial

Authors: Amirhossein Rahimnia, Motahareh Hosnian, Amir houshang Ehsani, Pedram Nourmohammadpour, Zahra Shadlou, Mina Koohian Mohammadabadi, Ala Ehsani

Melasma Treatment

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AI Tools Ala Ehsani Amir houshang Ehsani Amirhossein Rahimnia Artificial Intelligence Dermatology Helath Hematology Hemostasis Hemostasis Today Journal of Cosmetic Dermatology Max Thorne Medicine Melasma Mina Koohian Mohammadabadi Motahareh Hosnian NAFL Non-Ablative Fractional Laser Non-Ablative Laser Pedram Nourmohammadpour Randomized Trial Skin thrombosis tranexamic acid Zahra Shadlou

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