Oğuzhan Işılay on Stabilizing Human Blood Clotting Factor VIII
Oğuzhan Işılay, Bioinformatics Intern at Mersin Üniversity, shared on LinkedIn:
”I recently read and analyzed an interesting research paper on stabilizing Human Blood Clotting Factor VIII (FVIII) using proteins derived from tardigrades.
FVIII is a critical therapeutic protein used in the treatment of Hemophilia A, but it is highly unstable and requires strict cold-chain storage.
This creates major logistical and economic challenges, especially in low-resource settings.
The study explored whether proteins associated with desiccation tolerance in tardigrades (such as CAHS and SAHS proteins) could protect FVIII during repeated drying and rehydration cycles.
Remarkably, some tardigrade proteins preserved FVIII activity significantly better than commonly used stabilizers like trehalose, even after multiple stress cycles.
What I found particularly interesting is the broader implication: bio-inspired stabilization strategies could reduce cold-chain dependency and improve global access to protein-based therapeutics.
This analysis reinforced how concepts from extremophile biology can be directly translated into real-world biotechnological and medical solutions.
Reference.”
Read the full article here.
Article: Natural and engineered mediators of desiccation tolerance stabilize Human Blood Clotting Factor VIII in a dry state
Authors: Maxwell H. Packebush, Silvia Sanchez-Martinez, Sourav Biswas, Shraddha KC, Kenny H. Nguyen, John F. Ramirez, Vincent Nicholson, Thomas C. Boothby
Stay updated on all scientific advances with Hemostasis Today.
-
Jan 5, 2026, 15:33Mona Ahmed on Why Some Calcified Nodules Trigger ACS and Others Do Not
-
Jan 5, 2026, 14:17Abdul Mannan – VWF:RCo for Diagnosing von Willebrand Disease: That Test Might Be Failing Your Patients
-
Jan 5, 2026, 13:57Ewang Yemi: CAD is Real and Dangerous – Keep Your Heart Beating
-
Jan 5, 2026, 13:42Dr. Martha Boeckenfeld Shares VetiGel Creation Experiment: How A 17-Year-Old Mixed Algae in a Small Hidden Lab
-
Jan 5, 2026, 12:55Chokri Ben Lamine Explains Washed PRBCs!
-
Jan 5, 2026, 12:30ASH: Be Part of The Next Cohort of Hematology Quality Improvement Leaders
-
Jan 5, 2026, 09:59WFH Released New Evidence-Based Guidelines on AAV Gene Therapy for Hemophilia
-
Jan 5, 2026, 09:51Pete Stibbs: We Still Tend to Talk About VTE Like It’s a Plumbing Problem
-
Jan 5, 2026, 09:40Christopher Pittman on Treating Varicose Veins Before Knee or Hip Replacement