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Pablo Corral: How Low Should LDL-C Go After Ischemic Stroke?
Pablo Corral/LinkedIn
Mar 2, 2026, 16:27

Pablo Corral: How Low Should LDL-C Go After Ischemic Stroke?

Pablo Corral, Pharmacology Professor at FASTA University, Past President of Argentine Lipid Society, shared on LinkedIn about a recent article by Victorien Monguillon et al, published in Circulation:

”How Low Should LDL-C Go After Ischemic Stroke?

Not theoretical anymore. Not opinion.

Data:

  • Lower LDL-C, fewer cardiovascular events
  • Lower LDL-C, fewer recurrent strokes
  • Benefit continues below 40 mg/dL

And importantly:

  • No excess hemorrhagic stroke
  • No safety signal
  • Consistent risk reduction

The real question is no longer how low is too low. It is:

Why are we still leaving stroke patients exposed to avoidable LDL risk?

After ischemic stroke: Aggressive LDL lowering is prevention

Title: Efficacy and Safety of Very Low Achieved LDL Cholesterol in Patients With Previous Ischemic Stroke

Authors: Victorien Monguillon, Peter Kelly, Michelle O’Donoghue, Jeong-Gun Park, Erin Bohula, Jeffrey Saver, Dan Atar, Anthony Keech, Peter Sever, Huei Wang, Gabriel Paiva da Silva Lima, Marc Sabatine, Robert Giugliano

Read the Full Article on Circulation

Pablo Corral: How Low Should LDL-C Go After Ischemic Stroke?

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Anthony Keech Dan Atar Erin Bohula Gabriel Paiva da Silva Lima Health Hematology Hemostasis Hemostasis News Hemostasis Today Huei Wang Jeffrey Saver Jeong-Gun Park LDL Marc Sabatine Medicine Michelle O’Donoghue Pablo Corral Peter Kelly Peter Sever Robert Giugliano stroke thrombosis Victorien Monguillon
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