Peisong Ma on GRK5 Polymorphism Affecting Platelets
Peisong Ma, Associate Professor at Thomas Jefferson University, shared on LinkedIn:
”Excited to share that our latest manuscript, “Understanding how a highly prevalent GRK5 polymorphism affects platelets and enhances thrombotic risk,” is now published in the Blood Journal (online first).
In this study, we identify GRK5 as a previously unrecognized regulator of platelet PAR1 signaling and provide the first experimental evidence linking this common A→G variant to enhanced thrombin/PAR1 signaling and increased thrombus formation in vivo.
Using human GG donor platelets, iPSC-derived megakaryocytes, GRK5 inhibition, a humanized mouse model, and two preclinical models, our work connects human genetics → platelet GPCR regulation → thrombotic disease. These findings highlight GRK5 as a potential contributor to stroke and venous thromboembolism risk, with implications for future thrombophilia assessment.
Huge congratulations to my PhD students Yanki Yarman and Xuefei Zhao, and sincere thanks to our collaborators at Jefferson, CHOP, Cambridge, Mount Sinai, UPenn, and Purdue.”
Read the full article here.
Article: Understanding how a highly prevalent GRK5 polymorphism affects platelets and enhances thrombotic risk
Authors: Yanki Yarman, Xuefei Zhao, Hyunsook Ahn, Hannah A Thomson, Amrita Sarkar, Tian Yuan, Meghan E. Roberts, Jeremy Wurtzel, Scott L Diamond, John J.G Tesmer, Deborah L French, Maurizio Tomaiuolo, Ernest Turro, William Astle, Lawrence E. Goldfinger, Steven E. McKenzie, Jeffrey Benovic, Timothy J. Stalker, Mortimer Poncz, Peisong Ma
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