A Self-Regulatory Mechanism of The PolyP-Thrombin-Fibrin Complex – JTH
Journal of Thrombosis and Haemostasis (JTH) shared a post on LinkedIn about a recent article by Xintong Yao et al, adding:
”Formation of a Ternary Polyphosphate-Thrombin-Fibrin Complex Attenuates Thrombin Activity
Platelet-released polyphosphate, like heparin, promotes formation of a ternary polyP-thrombin-fibrin complex that simultaneously protects clot-bound thrombin from antithrombin inhibition while reducing its capacity to generate new fibrin, revealing a novel self-regulatory mechanism in coagulation.”
Title: Formation of a ternary polyphosphate-thrombin-fibrin complex attenuates thrombin activity
Authors: Xintong Yao, James C. Fredenburgh, Jeffrey I. Weitz
Read the Full Article on JTH
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