Rachel Lamerton and Colleagues on Activation of Platelets in Flow Cytometry
RPTH Journal shared on LinkedIn:
”Multivalent nanobodies targeting GPVI and CLEC-2 drive potent platelet activation.
Using classical and multispectral flow cytometry, tetravalent nanobodies produced stronger, more consistent activation than trivalent forms—while PEAR1 responses were more variable.
First Author: Rachel Lamerton”
Read the full article in RPTH.
Article: A minimum valency of 4 is required for robust activation of platelets in flow cytometry by multivalent nanobodies to Glycoprotein VI, C-type lectin-like receptor 2 and Platelet Endothelial Aggregation Receptor 1
Authors: Rachel Lamerton, Eleyna M. Martin, Jacqueline Perry, Adam F. Cunningham, Steve P. Watson, Andrew L. Frelinger III
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