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Ramesh Chennupat: Anemia is Associated with Increased REV Release in Stable Coronary Artery Disease
Ramesh Chennupat; Isabella Solga; Mohammed Rabiul Hosen/LinkedIn
Jun 28, 2026, 02:36

Ramesh Chennupat: Anemia is Associated with Increased REV Release in Stable Coronary Artery Disease

Ramesh Chennupat, Group Leader at Cardiology Department at University Hospital Düsseldorf, shared a post on LinkedIn about a recent article he and his colleagues co-authored, published in Journal of Molecular and Cellular Cardiology, adding:

“I am pleased to share our latest work from my research group:

‘Large extracellular vesicles derived from red blood cells in coronary artery disease patients with anemia promote endothelial dysfunction.’

Accepeted in the Journal of Molecular and Cellular Cardiology. JMCC Journals

Our study demonstrates that anemia in patients with stable coronary artery disease is associated with increased release of red blood cell–derived extracellular vesicles (REVs).

These anemic REVs show enhanced nitric oxide consumption and carry oxidative sterss promoting myeloperoxidase, leading to endothelial dysfunction both in vitro and in vivo.

Targeting MPO-driven oxidative stress within REVs was able to reverse these detrimental effects, highlighting a potential therapeutic avenue.

Overall, our findings reveal a novel mechanistic link between anemia, red blood cell vesiculation, and vascular dysfunction in coronary artery disease.”

Title: Large extracellular vesicles derived from red blood cells in coronary artery disease patients with anemia promote endothelial dysfunction

Authors: Isabella Solga, Leon Götzmann, Vithya Yogathasan, Patricia Wischmann, Tin Yau Pang, Patricia Kleimann, Sebastian Temme, Lina Hofer, Anja Stefanski, Alexander Lang, Georg Nickenig, Christian Jung, Norbert Gerdes, Mohammed Rabiul Hosen, Malte Kelm, Ramesh ChennupatiRamesh Chennupat: Anemia is Associated with Increased REV Release in Stable Coronary Artery Disease

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Alexander Lang Anja Stefanski Christian Jung Endothelial Dysfunction Georg Nickenig Health Hematology Hemostasis Hemostasis News Hemostasis Today Isabella Solga Leon Götzmann Lina Hofer Malte Kelm Mohammed Rabiul Hosen Norbert Gerdes Patricia Kleimann Patricia Wischmann Ramesh Chennupati REVs Sebastian Temme Tin Yau Pang Vithya Yogathasan
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