Ramesh Chennupat: Anemia is Associated with Increased REV Release in Stable Coronary Artery Disease
Ramesh Chennupat, Group Leader at Cardiology Department at University Hospital Düsseldorf, shared a post on LinkedIn about a recent article he and his colleagues co-authored, published in Journal of Molecular and Cellular Cardiology, adding:
“I am pleased to share our latest work from my research group:
‘Large extracellular vesicles derived from red blood cells in coronary artery disease patients with anemia promote endothelial dysfunction.’
Accepeted in the Journal of Molecular and Cellular Cardiology. JMCC Journals
Our study demonstrates that anemia in patients with stable coronary artery disease is associated with increased release of red blood cell–derived extracellular vesicles (REVs).
These anemic REVs show enhanced nitric oxide consumption and carry oxidative sterss promoting myeloperoxidase, leading to endothelial dysfunction both in vitro and in vivo.
Targeting MPO-driven oxidative stress within REVs was able to reverse these detrimental effects, highlighting a potential therapeutic avenue.
Overall, our findings reveal a novel mechanistic link between anemia, red blood cell vesiculation, and vascular dysfunction in coronary artery disease.”
Title: Large extracellular vesicles derived from red blood cells in coronary artery disease patients with anemia promote endothelial dysfunction
Authors: Isabella Solga, Leon Götzmann, Vithya Yogathasan, Patricia Wischmann, Tin Yau Pang, Patricia Kleimann, Sebastian Temme, Lina Hofer, Anja Stefanski, Alexander Lang, Georg Nickenig, Christian Jung, Norbert Gerdes, Mohammed Rabiul Hosen, Malte Kelm, Ramesh Chennupati
Stay updated with Hemostasis Today.
-
Sep 22, 2026, 07:18X. Long Zheng: From ADAMTS13 to New TTP Treatment
-
Sep 22, 2026, 07:11Platelet Dependent Protection Against Bacterial Pneumonia – JTH
-
Sep 22, 2026, 07:10Sumita Pandey: Apheresis Beyond Automation
-
Sep 22, 2026, 07:04Wafik El-Deiry: Type 1 interferon Alters Clonal Competition in Human Blood Development
-
Sep 22, 2026, 06:53Tania L.: Women in Hematology Take the Stage in Austin
-
Sep 22, 2026, 06:35Mahmoud Hanafy: Hayat National Hospitals Achieves AABB Accreditation
-
Sep 22, 2026, 06:01Nikola Pantic: New ASH ITP Guidelines Transform First-Line Treatment
-
Sep 22, 2026, 04:43Michael Cahillane: Highlights From BBTS2026 in Glasgow
-
Sep 22, 2026, 04:15Wolfgang Miesbach: First AAV Gene Therapy Data in Adolescents With Haemophilia B