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A Potential Link to Recurrent Pregnancy Loss: Monoclonal Anti-PF4 Antibodies’ Role
The New England Journal of Medicine
Jul 19, 2025, 16:16

A Potential Link to Recurrent Pregnancy Loss: Monoclonal Anti-PF4 Antibodies’ Role

Flora Peyvandi, Professor of Internal Medicine-Hemostasis and Thrombosis Unit, University of Milan, former President of ISTH, shared a post on X:

”Monoclonal Anti –Platelet Factor 4 Antibodies in Recurrent Pregnancy Loss.”

Read the full article here.

In a newly published article ”Monoclonal Anti–Platelet Factor 4 Antibodies in Recurrent Pregnancy Loss ” in The New England Journal of Medicine (NEJM) by Natalie R. Bavli et al., the role of monoclonal anti-platelet factor 4 antibodies in cases of recurring misscarriage is discussed.

Emerging evidence suggests that monoclonal anti–platelet factor 4 (PF4) antibodies may play a role in persistent thrombotic thrombocytopenia.

In a recent report, two patients with monoclonal anti-PF4 antibody-mediated thrombosis also experienced chronic intermittent thrombocytopenia and recurrent first-trimester pregnancy losses.

This combination of clinical findings points to a potential association between these antibodies and obstetrical complications, including recurrent pregnancy loss.

Further research in larger cohorts is needed to better understand this possible connection and its implications for maternal health.

A Potential Link to Recurrent Pregnancy Loss: Monoclonal Anti-PF4 Antibodies' Role

More on the latest scientific advancements in the field of thrombosis featured in Hemostasis Today.

Adam J. Kanack Alessandra J. Ainsworth Anand Padmanabhan Anti PF4 Antibodies David Murray Dong Chen Emily E. Mauch Health Hematology Hemostasis Today Medicine Mindy C. Kohlhagen Natalie R. Bavli NEJM Noah P. Splinter Rajiv K. Pruthi Ravi Sarode Recurrent Pregnancy Loss Robert D. McBane II Yoshito Nishimura
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