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Sebastian Klapa: Key Findings On Mortality And Cardiovascular Risk In ANCA-Associated Vasculitis
Sebastian Klapa/LinkedIn
Apr 16, 2026, 15:29

Sebastian Klapa: Key Findings On Mortality And Cardiovascular Risk In ANCA-Associated Vasculitis

Sebastian Klapa, Specialist in Internal Medicine and Rheumatology at University of Lübeck, shared a post on LinkedIn about a recent article he and his colleagues co-authored, adding:

“Hot off the press

ANCA-associated vasculitis (AAV) and the risk of mortality and cardiovascular morbidity.

In our recent paper, which has been accepted by Frontiers-Immunology, we focused on real-world data for mortality and a wide range of cardiovascular diseases in an enlarged cohort of over 20,000 AAV patients over a period of up to 20 years.

For the first time, we were able to compare over 5,000 MPA patients with GPA patients.

Key findings:

  • Increased risk of death in AAV patients
  • Elevated risk of all screened cardiovascular comorbidities, especially major adverse cardiac events (MACE)
  • MPA patients presented an increased risk of MACE and peripheral arterial disease

Be aware of your AAV patients, even those in stable remission.

In addition to symptom-related diagnostics, we may need to regularly screen for cardiovascular diseases.

Many thanks to all the co-authors for their great contributions!”

Title: ANCA-associated vasculitis is associated with an increased risk of cardiac and vascular morbidity: results of a large-scale propensity-matched global retrospective cohort study

Authors: Sebastian Klapa, Katja Bieber, Artem Vorobyev, Marlene Ludwig, Gordon Vollert, Sabrina Arnold, Henning Olbrich, Henry Nording, Antje Müller, Khalaf Kridin, Jan Henrik Schirmer, Katja von Allwörden, Anja Staehle, Ralf Ludwig, Peter Lamprecht

Sebastian Klapa: Key Findings On Mortality And Cardiovascular Risk In ANCA-Associated Vasculitis

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AAV ANCA-Associated Vasculitis Anja Staehle Antje Müller Artem Vorobyev Gordon Vollert Health Hematology Hemostasis Hemostasis News Hemostasis Today Henning Olbrich Henry Nording Jan Henrik Schirmer Katja Bieber Katja von Allwörden Khalaf Kridin Marlene Ludwig Medicine Peter Lamprecht Ralf Ludwig Sabrina Arnold Sebastian Klapa
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