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Shaymaa Alhabib on Piezo1 Mutation and Platelet Preactivation State

Shaymaa Alhabib/LinkedIn

Dec 24, 2025, 13:06

Shaymaa Alhabib on Piezo1 Mutation and Platelet Preactivation State

Shaymaa Alhabib, Student at Bicêtre Hospital, shared on LinkedIn:

”I’m happy to share a study I participated in, now published in the Journal of Thrombosis and Haemostasis

This study shows that Piezo1 gain-of-function mutations prolong channel opening, leading to sustained calcium entry into platelets.

This primes platelets into a preactivated state, helping explain the thrombotic risk in hereditary xerocytosis patients.

A huge thanks to my supervisor Régis Bobe, for the opportunity to be part of this work, and of course to the group headed by Dr. Chrislla Bachelot-Loza for their excellent work!”

Read the full article here.

Article: Piezo1 gain of function induces a platelet preactivation state

Authors: Christilla Bachelot-Loza, Aurore Marchelli, Laurie Ruch, Divina El Hamaoui, Julien Demagny, Bruna Salau Grau, Clarisse Mouriaux, Wafa Amara, Anaïs Mehl, Emma Ziessel, Shaymaa Alhabib, My Ngoc Ha, Fatima Zemali, Sophie Gandrille, Véronique Picard, Pierre Mangin, Régis Bobe, Loïc Garçon, Catherine Léon, Pascale Gaussem

Shaymaa Alhabib on Piezo1 Mutation and Platelet Preactivation State