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Wolfgang Miesbach: How Does Protein S Inhibition Restore Hemostasis in von Willebrand Disease?
Wolfgang Miesbach, Yumiko Sakurai/LinkedIn
Mar 28, 2026, 17:07

Wolfgang Miesbach: How Does Protein S Inhibition Restore Hemostasis in von Willebrand Disease?

Wolfgang Miesbach, Professor of Medicine at Frankfurt University Hospital, shared a post on LinkedIn about a recent article by Yumiko Sakurai, published in Blood:

“How Does Protein S Inhibition Restore Hemostasis in von Willebrand Disease?

At EAHAD2026, fascinating microfluidics data from Emory University shed light on VGA039’s mechanism in VWD.

The connection isn’t immediately obvious:

VWD stems from insufficient platelet adhesion due to low or dysfunctional VWF.

Protein S is a cofactor for activated protein C, regulating thrombin generation.

Findings from the Ex Vivo Model, The haemostasis-on-a-chip data demonstrated that VGA039:

  • Significantly shortened bleeding times in VWD patient blood
  • Accelerated platelet deposition (p<0.004)
  • Enhanced fibrin accumulation (p<0.008)
  • Restored haemostasis through dual inhibition of TFPI and aPC pathways

The Mechanistic Insight:

The answer lies at the microvascular level.

By neutralizing Protein S’s dual activities (cofactor for protein C and TFPI inhibitor), VGA039 allows enhanced local thrombin generation specifically at microvascular sites – precisely where VWF normally enables platelet adhesion and where most bleeding occurs in VWD patients.

Congratulations to Yumiko Sakurai and co-authors.”

Title: A protein S-targeting monoclonal antibody, VGA039, improves both primary and secondary hemostatic activity of von Willebrand disease patient blood in an ex vivo vascularized hemostasis-on-a-chip

Authors: Yumiko Sakurai, Megan Brown, Yongzhi Qiu, Elaissa Hardy, Tony Byun, Sandip Panicker, Wilbur Lam

Read the Full Article on Blood

Wolfgang Miesbach: How Does Protein S Inhibition Restore Hemostasis in von Willebrand Disease?

Find more posts featuring Wolfgang Miesbach on Hemostasis Today.

 

Blood EAHAD2026 Elaissa Hardy Health Hematology Hemostasis Hemostasis News Hemostasis Today Medicine Megan Brown protein S Sandip Panicker TFPI inhibitor thrombosis Tony Byun Transfusion Medicine VGA039 Von Willebrand Disease VWF Wilbur Lam Yongzhi Qiu Yumiko Sakurai
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