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Wolfgang Miesbach: Protecting Liver Health in Bleeding Disorders
Wolfgang Miesbach/LinkedIn
Jul 31, 2025, 15:12

Wolfgang Miesbach: Protecting Liver Health in Bleeding Disorders

Wolfgang Miesbach, Professor of Medicine at Frankfurt University Hospital, shared a proud post on LinkedIn:

”World Hepatitis Day 2025 – Protecting Liver Health in Bleeding Disorders. Despite curative therapies for hepatitis B and C, people with congenital bleeding disorders (PWBD) remain at elevated risk for liver complications—including fibrosis, cirrhosis, and hepatocellular carcinoma (HCC). Landmark data show that even after viral eradication, factors such as metabolic dysfunction, obesity, diabetes, and alcohol drive ongoing liver injury.

New International Guidance (EAHAD, EHC, ISTH, WFH) by La Mura et al. provides a unified, evidence-based framework to proactively monitor, prevent, and manage liver complications in PWBD:

– Universal viral hepatitis screening for all PWBD exposed to blood derivatives, including assessment for occult HBV prior to immunosuppression/gene therapy
– Routine metabolic assessment (focus on MASLD and alcohol), as non-viral liver disease now rivals viral hepatitis in this population
– Non-invasive fibrosis stratification using FIB-4 and FibroScan, reducing need for biopsies and identifying patients at risk of progression
– HCC surveillance (liver ultrasound + AFP every 6 months) for those with advanced fibrosis or cirrhosis—even post-cure
– Gene therapy safety: Comprehensive liver evaluation is essential pre- and post-AAV gene therapy; advanced liver disease remains a contraindication”

Read the full article here.

Article: ”The management of liver disease in people with congenital bleeding disorders: guidance from European Association for Haemophilia and Allied Disorders, European Haemophilia Consortium, ISTH, and World Federation of Hemophilia”

Journal: JTH (Journal of Thrombosis and Haemostasis)

Authors: Vincenzo La Mura, Massimo Colombo, Graham R. Foster, Paolo Angeli, Wolfgang Miesbach, Robert Klamroth, Glenn F. Pierce, Brian O’Mahony, Ming Y. Lim, Virginia Hernandez-Gea, Michael Makris, Flora Peyvandi

Wolfgang Miesbach: Protecting Liver Health in Bleeding Disorders

Stay updated on the latest scientific advancements in the field of bleeding disorders with Hemostasis Today.

bleeding disorders Brian O’Mahony congenital bleeding disorders EAHAD EHC Flora Peyvandi Glenn F. Pierce Graham R. Foster HBV Health Hematology Hemostasis Today hepatocellular carcinoma ISTH Journal of Thrombosis and Haemostasis JTH jth Journal Liver Health in Bleeding Disorders Massimo Colombo Medicine Michael Makris Ming Y. Lim Paolo Angeli Robert Klamroth Vincenzo La Mura Virginia Hernandez-Gea WFH Wolfgang Miesbach World Hepatitis Day
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