Wolfgang Miesbach: Can Gene Therapy Redefine Aging and Healthy Longevity?
Wolfgang Miesbach, Professor of Medicine at Frankfurt University Hospital, shared a post on LinkedIn about a recent article by Yan Zhang et al., published in Ageing Research Reviews:
“Gene Therapy Meets Aging Biology.
A recent review explores how genetic tools could one day modify core aging mechanisms, not just individual diseases.
- AAV‑based delivery to add ‘protective’ genes (e.g. factors supporting mitochondria, telomeres, or stress resistance) to vulnerable organs.
- Gene silencing/editing (CRISPR, base editors, RNA tools) to switch off toxic proteins and disease‑driving variants seen in neurodegeneration and cardiomyopathy.
- Partial reprogramming signals that nudge cells toward a more ‘youthful’ gene‑expression state while preserving their identity.
What excites me most is the paradigm shift: these approaches aim at upstream biology that feeds many conditions at once.
If we can balance efficacy, safety, and ethics, this could redefine prevention and ‘healthy longevity‘ in clinical practice.”
Title: Gene therapy for aging: Current evidence and future directions
Authors: Yan Zhang, Lianli Gan, Shixuan Wang, Jinjin Zhang
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