Yaping Zhang on Platelet Adhesion Receptors
Yaping Zhang, Postdoc Associate at University of Illinois Chicago, shared on LinkedIn:
”Glad to participate in publishing the chapter “Platelet Adhesion Receptors” in the book Platelet Physiology I.
Andrew Mack, Yaping Zhang & Xiaoping Du
Platelet adhesion receptors are essential for platelet attachment, aggregation, and activation, which are critical for normal hemostasis and pathological thrombosis.
These receptors regulate where and how platelets adhere, influencing thrombus size and stability, and they trigger signaling pathways that coordinate with other adhesion and activation receptors to promote platelet spreading, secretion, clot retraction, and thrombus formation.
Platelets use several major receptor families—including integrins, LRR receptors such as GPIb-IX-V, immunoglobulin superfamily receptors like GPVI, and C-type lectins—to bind ligands such as collagen, von Willebrand factor, fibrinogen, and laminin, enabling interactions with vessel walls, other platelets, leukocytes, microbes, and tumor cells.
Because adhesion is central not only to hemostasis and thrombosis but also to inflammation and immune responses, targeting these receptors and their signaling pathways remains a key strategy for developing antithrombotic therapies.”
Read the chapter here.
Article: Platelet Adhesion Receptors
Authors: Andrew Mack, Yaping Zhang, Xiaoping Du
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