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Yaping Zhang on Two-Way GPIb-IX Signaling in Platelet Activation and VWF Binding
Yaping Zhang/LinkedIn
Nov 6, 2025, 04:03

Yaping Zhang on Two-Way GPIb-IX Signaling in Platelet Activation and VWF Binding

Yaping Zhang, Postdoc Associate at University of Illinois Chicago, shared on LinkedIn:

”Applaud everyone!

I am proud to share that our NEW paper “Direct Binding of Lyn to GPIbβ Transmits Two-Way GPIb-IX Signaling to Stimulate Platelet Activation and VWF Binding”, is published in Circulation Research and ONLINE today!

Yaping Zhang, Ying Liang, Amir Hossein Kazemipour Ashkezari, Can Wang, Claire Chang, Yanyan Bai, Xin Huang, Andrew Mack, Haotian Yang, Peiwen Cong, Ni Cheng, Cheng Zhu, and Xiaoping Du

A huge thank you to all my co-authors listed above who helped me publish this work!

Especially thanks to our collaborator Dr. Cheng Zhu’s group from the Georgia Institute of Technology (Amir Hossein Kazemipour Ashkezari and Dr. Peiwen Cong) for their contributions.

We also thank the reviewers and editors from Circulation Research for your support and publication of our work.

Novelty and Significance
•This article demonstrates that Lyn directly binds to the GPIb (glycoprotein Ib) β subunit at the transmembrane-cytoplasmic domain interface.
•This article shows that this Lyn-GPIbβ interaction is essential for bidirectional GPIb-IX signaling that strengthens GPIb-IX-VWF interaction and mediates platelet activation and aggregation in response to VWF and collagen.
•This article invents a novel peptide drug that blocks Lyn binding to GPIbβ and inhibits platelet adhesion/aggregation and arterial thrombosis with potential for treating thrombotic diseases.”

Read the full article in Circulation Research.

Article: Direct Binding of Lyn to GPIbβ Transmits Two-Way GPIb-IX Signaling to Stimulate Platelet Activation and VWF Binding

Authors: Yaping Zhang, Ying Liang, Amir Hossein Kazemipour Ashkezari, Can Wang, Claire Chang, Yanyan Bai, Xin Huang, Andrew Mack, Haotian Yang, Peiwen Cong, Ni Cheng, Cheng Zhu, Xiaoping Du

Yaping Zhang on Two-Way GPIb-IX Signaling in Platelet Activation and VWF Binding

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Amir Hossein Kazemipour Ashkezari Andrew Mack bleeding disorders Can Wang Cheng Zhu Circulation Research Claire Chang Georgia Institute of Technology GPIb-IX GPIbβ Haotian Yang Health Hematology Hemostasis Hemostasis Today Lyn Medicine Ni Cheng Peiwen Cong Platelet Activation VWF Xiaoping Du Xin Huang Yanyan Bai Yaping Zhang Ying Liang
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