Yaping Zhang on Two-Way GPIb-IX Signaling in Platelet Activation and VWF Binding
Yaping Zhang, Postdoc Associate at University of Illinois Chicago, shared on LinkedIn:
”Applaud everyone!
I am proud to share that our NEW paper “Direct Binding of Lyn to GPIbβ Transmits Two-Way GPIb-IX Signaling to Stimulate Platelet Activation and VWF Binding”, is published in Circulation Research and ONLINE today!
Yaping Zhang, Ying Liang, Amir Hossein Kazemipour Ashkezari, Can Wang, Claire Chang, Yanyan Bai, Xin Huang, Andrew Mack, Haotian Yang, Peiwen Cong, Ni Cheng, Cheng Zhu, and Xiaoping Du
A huge thank you to all my co-authors listed above who helped me publish this work!
Especially thanks to our collaborator Dr. Cheng Zhu’s group from the Georgia Institute of Technology (Amir Hossein Kazemipour Ashkezari and Dr. Peiwen Cong) for their contributions.
We also thank the reviewers and editors from Circulation Research for your support and publication of our work.
Novelty and Significance
•This article demonstrates that Lyn directly binds to the GPIb (glycoprotein Ib) β subunit at the transmembrane-cytoplasmic domain interface.
•This article shows that this Lyn-GPIbβ interaction is essential for bidirectional GPIb-IX signaling that strengthens GPIb-IX-VWF interaction and mediates platelet activation and aggregation in response to VWF and collagen.
•This article invents a novel peptide drug that blocks Lyn binding to GPIbβ and inhibits platelet adhesion/aggregation and arterial thrombosis with potential for treating thrombotic diseases.”
Read the full article in Circulation Research.
Article: Direct Binding of Lyn to GPIbβ Transmits Two-Way GPIb-IX Signaling to Stimulate Platelet Activation and VWF Binding
Authors: Yaping Zhang, Ying Liang, Amir Hossein Kazemipour Ashkezari, Can Wang, Claire Chang, Yanyan Bai, Xin Huang, Andrew Mack, Haotian Yang, Peiwen Cong, Ni Cheng, Cheng Zhu, Xiaoping Du
Stay updated on all scientific advances with Hemostasis Today.
-
Jul 9, 2026, 11:26Peter Zhang: Is Canada Ready for the Gene Therapy Era?
-
Jul 9, 2026, 09:35Pradeebha Muthukumar: Do You Know the Signs of Anemia?
-
Jul 9, 2026, 09:24Maryam Majid: Machine Learning for Anemia Risk Prediction
-
Jul 9, 2026, 08:46Jordan Agay: Folate Deficiency in Patients Receiving PARP Inhibitors
-
Jul 9, 2026, 08:29Laura Katz: Is Human Lactoferrin Better Than Bovine Lactoferrin?
-
Jul 9, 2026, 08:17Anziya Sabeer: AI-Driven Non-Invasive Anemia Detection
-
Jul 9, 2026, 07:37Variable Mechanisms of ADAMTS13 Inhibition by Autoantibodies in iTTP – JTH
-
Jul 9, 2026, 07:31DHR-Sponsored Training Programme at ICMR-CRMCH Week 2 – Day 4 – ICMR-NIRBID
-
Jul 9, 2026, 06:03Barbara Adams Krolak: ISTH Launches Global Women’s Health Hub