Jun 16, 2025, 09:37
Methamphetamine Abuse Triggers Severe Thrombotic Microangiopathy
Sanjeev Sethi, Professor of Pathology and Renal Pathologist at Mayo Clinic, shared a clinical case on X.
“Methamphetamine abuse=severe thrombotic microangiopathy
Unfortunate weekend case. Glomeruli: mesangiolysis and ischemic changes
Interstitium: Hemorrhage, inflammation & scarring
Vessels: Severe sclerosis, thrombosis, schistocytes40-yr woman, hypertension, AKI, meth abuse”
In this biopsy from a 40-year-old hypertensive patient with acute kidney injury and chronic methamphetamine use, histology revealed:
- Glomeruli: marked mesangiolysis and ischemic collapse
- Interstitium: extensive hemorrhage, inflammatory infiltrates, and fibrosis
- Vessels: complete arterial occlusion, widespread thrombosis, and vascular sclerosis, with schistocyte formation
This case underscores the devastating microvascular injury drugs like methamphetamine can inflict, mimicking classic thrombotic microangiopathy. Early recognition of drug-induced TMA is critical—prompt discontinuation of the offending agent and supportive care may improve renal outcomes.
Stay up to date with Hemostasis Today for more case reviews.
-
Jun 19, 2025, 03:39ASH Recognizes 11 Hematologists for Transformative Contributions to Blood Disorder Research
-
Jun 17, 2025, 10:3025 Posts Not to Miss from EHA 2025
-
Jun 17, 2025, 05:10Recombinant ADAMTS13 Shows Superior Efficacy Over Plasma in Congenital TTP: A Paradigm Shift in Replacement Therapy - Blood Journals Portfolio
-
Jun 16, 2025, 17:00Hypoxia and Emergency Caesarean Deliveries Worsen Postpartum Outcomes in Sickle Cell Disease: New Insights from Perinatal Hemostasis Research
-
Jun 16, 2025, 10:42Jorge Cortes: The First Issue of Blood Global Hematology is Out
-
Jun 18, 2025, 15:49Abdul Mannan: Laboratory Alert - DOAC Interference in Heparin Monitoring
-
Jun 18, 2025, 08:19William Aird: Thrombocytosis - Know the difference, think before you refer
-
Jun 16, 2025, 18:24Talha Badar: TKI Selection Based on Mutation Profiles in CML at EHA 2025
-
Jun 16, 2025, 16:24Yelak Biru: Anito-Cel Drives Durable Responses in R/R Multiple Myeloma
-
Jun 15, 2025, 09:32Silent Threat: Underrated Risk of Thrombosis in IBD Outpatients Revealed by New Data - Thrombosis Update
-
Mar 6, 2025, 17:15Olympus Announces Launch of Single-Use Hemostasis Clip
-
Jun 18, 2025, 10:30Join "Where Cardiologists and Hematologists Meet" Session Organized by ESC and EHA
-
Jun 18, 2025, 09:01Nihar Desai: A 35 Year Old Man Presents with High Grade Fever...
-
Jun 17, 2025, 18:38Anastasia Conti: The European Hematology Association Congress Was Amazing
-
Jun 17, 2025, 17:07Mark Wildgust: Outstanding Results from the FLAIR Study Presented at EHA25
-
Jun 17, 2025, 15:03Hamayak Sisakian Announces ESC Heart Failure Center Accreditation
Jun 18, 2025, 15:49
Jun 18, 2025, 10:50
Jun 18, 2025, 09:01
Jun 18, 2025, 08:19
Jun 17, 2025, 18:38
Jun 17, 2025, 17:07
Jun 17, 2025, 15:03
Jun 17, 2025, 10:30
Jun 17, 2025, 06:55